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1. (WO2012101199) AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/101199    International Application No.:    PCT/EP2012/051191
Publication Date: 02.08.2012 International Filing Date: 26.01.2012
IPC:
C07D 231/14 (2006.01), C07D 275/03 (2006.01)
Applicants: SANOFI [FR/FR]; 54, rue La Boétie F-75008 Paris (FR) (For All Designated States Except US).
RUF, Sven [DE/DE]; (DE) (For US Only).
SADOWSKI, Thorsten [DE/DE]; (DE) (For US Only).
HORSTICK, Georg [DE/DE]; (DE) (For US Only).
SCHREUDER, Herman [NL/DE]; (DE) (For US Only).
BUNING, Christian [DE/DE]; (DE) (For US Only).
OLPP, Thomas [DE/DE]; (DE) (For US Only).
WIRTH, Klaus [DE/DE]; (DE) (For US Only)
Inventors: RUF, Sven; (DE).
SADOWSKI, Thorsten; (DE).
HORSTICK, Georg; (DE).
SCHREUDER, Herman; (DE).
BUNING, Christian; (DE).
OLPP, Thomas; (DE).
WIRTH, Klaus; (DE)
Agent: LÖWRICK, Oliver; c/o Sanofi-Aventis Deutschland GmbH Patents Germany Industriepark Höchst, Geb. K 801 65926 Frankfurt (DE)
Priority Data:
11305077.7 26.01.2011 EP
Title (EN) AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
(FR) DÉRIVÉS DE L'ACIDE 3-HÉTÉROAROYLAMINO-PROPIONIQUE AMINO SUBSTITUÉS ET LEUR UTILISATION EN TANT QUE PRODUITS PHARMACEUTIQUES
Abstract: front page image
(EN)Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals The present invention relates to compounds of the formula (I), wherein A, D, E, G, R10 R11, R30 R40 R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
(FR)La présente invention concerne des dérivés de l'acide 3-hétéroaroylamino-propionique amino substitués et leur utilisation en tant que produits pharmaceutiques. La présente invention concerne des composés pharmaceutiquement actifs intéressants de formule (I), dans laquelle A, D, E, G, R10 R11, R30 R40 R50 et R60 sont tels que définis dans les revendications. Il s'agit d'inhibiteurs de la protéase qu'est la cathepsine A et ils peuvent être utilisés pour le traitement de maladies comme l'athérosclérose, l'insuffisance cardiaque, les maladies rénales, les maladies hépatiques ou les maladies inflammatoires par exemple. L'invention concerne, en outre, des procédés de préparation des composés de formule I, leur utilisation et des compositions pharmaceutiques en contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)