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1. (WO2012101068) NOVEL TETRAHYDROQUINOLINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/101068    International Application No.:    PCT/EP2012/050922
Publication Date: 02.08.2012 International Filing Date: 23.01.2012
IPC:
C07D 215/48 (2006.01), C07D 401/04 (2006.01), C07D 401/10 (2006.01), C07D 413/10 (2006.01), C07D 471/04 (2006.01), A61K 31/47 (2006.01), A61K 31/4709 (2006.01), A61K 31/496 (2006.01), A61K 31/5377 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
FENG, Lichun [CN/CN]; (CN) (For US Only).
HUANG, Mengwei [CN/CN]; (CN) (For US Only).
LIU, Yongfu [CN/CN]; (CN) (For US Only).
WU, Guolong [CN/CN]; (CN) (For US Only).
YAN, Shixiang [CN/CN]; (CN) (For US Only).
YUN, Hongying [CN/CN]; (CN) (For US Only).
ZHOU, Mingwei [CN/CN]; (CN) (For US Only)
Inventors: FENG, Lichun; (CN).
HUANG, Mengwei; (CN).
LIU, Yongfu; (CN).
WU, Guolong; (CN).
YAN, Shixiang; (CN).
YUN, Hongying; (CN).
ZHOU, Mingwei; (CN)
Agent: POMERANC, Didier; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
PCT/CN2011/070644 26.01.2011 CN
Title (EN) NOVEL TETRAHYDROQUINOLINE DERIVATIVES
(FR) DÉRIVÉS INÉDITS DE LA TÉTRAHYDROQUINOLINE
Abstract: front page image
(EN)A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the significance given in claim 1, can be used as AMPK modulators for treating obesity, hyperglycemia or type 2 diabetes.
(FR)La présente invention concerne un composé de formule (I) ou un ester ou un sel pharmaceutiquement acceptable de celui-ci, dans lequel R1 à R8 et A1 à A3 sont tels que définis à la revendication 1, ledit composé, ester ou sel pouvant être utilisé en tant que modulateur de l'activité de l'AMPK en vue du traitement de l'obésité, de l'hyperglycémie ou du diabète de type 2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)