WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012101029) TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/101029    International Application No.:    PCT/EP2012/050765
Publication Date: 02.08.2012 International Filing Date: 19.01.2012
IPC:
C07D 487/04 (2006.01), C07D 498/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: NERVIANO MEDICAL SCIENCES S.r.l. [IT/IT]; PO Box. 11 Viale Pasteur, 10 I-20014 Nerviano (MI) (IT) (For All Designated States Except US).
CALDARELLI, Marina [IT/IT]; (IT) (For US Only).
CASUSCELLI, Francesco [IT/IT]; (IT) (For US Only).
DONATI, Daniele [IT/IT]; (IT) (For US Only).
MIRIZZI, Danilo [IT/IT]; (IT) (For US Only).
QUARTIERI, Francesca [IT/IT]; (IT) (For US Only).
SILVAGNI, Marco [IT/IT]; (IT) (For US Only)
Inventors: CALDARELLI, Marina; (IT).
CASUSCELLI, Francesco; (IT).
DONATI, Daniele; (IT).
MIRIZZI, Danilo; (IT).
QUARTIERI, Francesca; (IT).
SILVAGNI, Marco; (IT)
Common
Representative:
NERVIANO MEDICAL SCIENCES S.r.l.; PO Box. 11 Viale Pasteur, 10 I-20014 Nerviano (MI) (IT)
Priority Data:
11152189.4 26.01.2011 EP
Title (EN) TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
(FR) DÉRIVÉS TRICYCLIQUES, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION À TITRE D'INHIBITEURS DE KINASES
Abstract: front page image
(EN)New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.
(FR)Cette invention concerne de nouveaux composés tricycliques substitués de formule (I), où R1, R2, X, Y, Z dans la formule sont tels que définis dans la présente, lesdits nouveaux composés ayant une activité inhibitrice des protéines kinases. Cette invention concerne également des procédés de préparation des composés de formule (I), des compositions pharmaceutiques les contenant, et leur utilisation en thérapie, en particulier, pour traiter les maladies provoquées par et/ou associées à une dérégulation de l'activité protéine kinase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)