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1. WO2012100835 - METHODS AND COMPOSITIONS FOR THE TREATMENT OF AIDS

Publication Number WO/2012/100835
Publication Date 02.08.2012
International Application No. PCT/EP2011/051237
International Filing Date 28.01.2011
IPC
A61K 31/164 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
164of a carboxylic acid with an aminoalcohol, e.g. ceramides
A61P 31/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61K 31/164
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
164of a carboxylic acid with an aminoalcohol, e.g. ceramides
A61K 31/4425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4425Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants
  • LABORATORIOS DEL DR. ESTEVE, S.A. [ES]/[ES] (AllExceptUS)
  • FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA [ES]/[ES] (AllExceptUS)
  • FABRIÀS DOMINGO, Gemma [ES]/[ES] (UsOnly)
  • GOÑI URCELAY, Félix [ES]/[ES] (UsOnly)
  • IZQUIERDO USEROS, Nuria [ES]/[ES] (UsOnly)
  • LLEBARIA SOLDEVILA, Amadeu [ES]/[ES] (UsOnly)
  • MAÑES BROTÓN, Santos [ES]/[ES] (UsOnly)
  • MARTÍNEZ PICADO, Javier [ES]/[ES] (UsOnly)
Inventors
  • FABRIÀS DOMINGO, Gemma
  • GOÑI URCELAY, Félix
  • IZQUIERDO USEROS, Nuria
  • LLEBARIA SOLDEVILA, Amadeu
  • MAÑES BROTÓN, Santos
  • MARTÍNEZ PICADO, Javier
Agents
  • ALCONADA RODRÍGUEZ, Agustín
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR THE TREATMENT OF AIDS
(FR) MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU SIDA
Abstract
(EN) The application relates to a method for the treatment of a disease caused by HIV infection by administering to a patient in need thereof of a specific inhibitor of the dehydroceramide desaturase. The invention relates as well to compositions comprising a Des-1inhibitor and one or more drugs suitable for the treatment of diseases caused by HIV infection as well as to methods for the identification of compounds suitable for the treatment of said diseases.
(FR) La présente invention concerne une méthode de traitement d'une maladie provoquée par une infection par le VIH, consistant à administrer à un patient en ayant besoin un inhibiteur spécifique de la dihydrocéramide désaturase. L'invention porte en outre sur des compositions comprenant un inhibiteur de Des-1, et un ou plusieurs médicaments adaptés au traitement de maladies provoquées par une infection par le VIH, ainsi que sur des méthodes d'identification de composés adaptés au traitement desdites maladies.
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