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1. (WO2012100368) METHOD FOR SCREENING TUMOR CELLS AND USE THEREOF.
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/100368    International Application No.:    PCT/CN2011/000119
Publication Date: 02.08.2012 International Filing Date: 25.01.2011
IPC:
G01N 33/68 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01), C07D 209/70 (2006.01), A61K 31/403 (2006.01), A61K 31/54 (2006.01), A61P 35/00 (2006.01)
Applicants: DALIAN UNIVERSITY OF TECHNOLOGY [CN/CN]; No.2 Linggong Road, Ganjingzi District Dalian, Liaoning 116024 (CN) (For All Designated States Except US).
ZHANG, Zhichao [CN/CN]; (CN) (For US Only).
SONG, Ting [CN/CN]; (CN) (For US Only)
Inventors: ZHANG, Zhichao; (CN).
SONG, Ting; (CN)
Agent: LEADING INTELLECTUAL PROPERTY FIRM; 909, 9th Floor, Tower B, Fortune Building No. 17, Daliushu Road Haidian District, Beijing 100081 (CN)
Priority Data:
Title (EN) METHOD FOR SCREENING TUMOR CELLS AND USE THEREOF.
(FR) PROCÉDÉ DE CRIBLAGE DE CELLULES TUMORALES ET SON UTILISATION
(ZH) 筛选肿瘤细胞的方法及其用途
Abstract: front page image
(EN)The present invention provides a method for screening tumor cells which can be induced to apoptosis with acenaphtho heterocycle compounds such as 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile, as well as the use and kits thereof. The method comprises detecting the apoptosis-inducing factor Bak in tumor cells, wherein if the expression of Bak is no less than 50% of the expression of actin, it is determined that the tumor cells can be induced to apoptosis with acenaphtho heterocycle compounds.
(FR)Cette invention concerne un procédé de criblage pour identifier les cellules tumorales qui peuvent être induites en apoptose par des composés acénaphto-hétérocycliques tels que le 3-thiomorpholin-8-oxo-8H-acénaphto- [1,2-b]pyrrole-9-carbonitrile, ainsi que son utilisation et des trousses associées. Le procédé comprend la détection du facteur inducteur d'apoptose Bak dans des cellules tumorales. Si l'expression de Bak n'est pas inférieure à 50 % de l'expression de l'actine, il est déterminé que les cellules tumorales peuvent être induites en apoptose par des composés acénaphto- hétérocycliques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)