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1. (WO2012100229) COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/100229    International Application No.:    PCT/US2012/022119
Publication Date: 26.07.2012 International Filing Date: 20.01.2012
IPC:
C07D 487/04 (2006.01), C07D 413/14 (2006.01), C07D 401/04 (2006.01), A61K 31/519 (2006.01), A61P 9/00 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, MA 02114 (US) (For All Designated States Except US).
YU, Paul, B. [US/US]; (US) (For US Only).
DERWALL, Mathias [DE/DE]; (DE) (For US Only).
BLOCH, Kenneth, D. [US/US]; (US) (For US Only).
MALHOTRA, Rajeev [US/US]; (US) (For US Only)
Inventors: YU, Paul, B.; (US).
DERWALL, Mathias; (DE).
BLOCH, Kenneth, D.; (US).
MALHOTRA, Rajeev; (US)
Agent: HALSTEAD, David, P.; Ropes & Gray LLP Prudential Tower 800 Boylston Street Boston, MA 02199 (US)
Priority Data:
61/434,932 21.01.2011 US
Title (EN) COMPOSITIONS AND METHODS FOR CARDIOVASCULAR DISEASE
(FR) COMPOSITIONS ET PROCÉDÉS CONTRE LES MALADIES CARDIOVASCULAIRES
Abstract: front page image
(EN)The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to reduce circulating levels of ApoB-100 or LDL. These compounds may also be used to treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.
(FR)La présente invention concerne des inhibiteurs à petites molécules de signalisation BMP. Lesdits composés peuvent être utilisés pour réduire les niveaux d'ApoB-100 ou de LDL en circulation. Ces composés peuvent également être utilisés pour traiter ou prévenir les affections suivantes : l'hyperlipoprotéinémie ou l'hypercholestérolémie acquise ou congénitale ; les maladies, les troubles ou les syndromes associés aux défauts d'absorption de lipides ou du métabolisme ; ou les maladies, les troubles ou les syndromes provoqués par l'hyperlipidémie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)