WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012100172) METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF HIF-1A BY DOUBLE STRANDED RNA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/100172    International Application No.:    PCT/US2012/022045
Publication Date: 26.07.2012 International Filing Date: 20.01.2012
IPC:
A61K 48/00 (2006.01), C12N 15/11 (2006.01), C07H 21/04 (2006.01)
Applicants: DICERNA PHARMACEUTICALS, INC. [US/US]; 480 Arsenal Street Watertown, MA 02742 (US) (For All Designated States Except US).
BROWN, Bob, Dale [US/US]; (US) (For US Only).
DUDEK, Henryk T. [US/US]; (US) (For US Only)
Inventors: BROWN, Bob, Dale; (US).
DUDEK, Henryk T.; (US)
Agent: WILLIAMS, Kathleen; Edwards Wildman Palmer LLP P.O.Box 55874 Boston, MA 02205 (US)
Priority Data:
61/435,304 22.01.2011 US
Title (EN) METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF HIF-1A BY DOUBLE STRANDED RNA
(FR) PROCÉDÉS ET COMPOSITIONS POUR L'INHIBITION SPÉCIFIQUE DE HIF-1A PAR UN ARN À DOUBLE BRIN
Abstract: front page image
(EN)The disclosure relates to compounds, compositions, and methods useful for reducing the levels of Hypoxia-Inducible Factor-la (HIF-la) RNA and protein. Further disclosed are dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents that are capable of reducing the expression of a target HIF-la gene in a cell, either in vitro or in a mammalian subject. The method of making and using the dsRNAs for treating disorders are also disclosed.
(FR)Cette invention concerne des composés, des compositions et des procédés utiles pour la réduction des taux d'ARN cible et de protéine HIS-1α par l'utilisation d'ARN à double brin, par exemple, des agents ARNsi de substrats Dicer (ARNDsi).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)