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1. (WO2012099785) MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/099785    International Application No.:    PCT/US2012/021207
Publication Date: 26.07.2012 International Filing Date: 13.01.2012
IPC:
C07D 209/20 (2006.01), C07D 333/58 (2006.01), A61K 31/404 (2006.01), A61K 31/381 (2006.01), A61P 31/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US/US]; 1800 Grant Street 8th Floor Denver, CO 80203 (US) (For All Designated States Except US).
YIN, Hang [CN/US]; (US) (For US Only).
CHENG, Kui [CN/US]; (US) (For US Only)
Inventors: YIN, Hang; (US).
CHENG, Kui; (US)
Agent: CHA, Don D.; 547 Buena Vista Road Golden, CO 80401 (US)
Priority Data:
61/434,492 20.01.2011 US
Title (EN) MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF
(FR) MODULATEURS DU COMPLEXE TLR3/ARNDS ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula (I) compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.
(FR)La présente invention concerne des composés et compositions qui peuvent moduler la formation du complexe récepteur 3 de type Toll (TLR3) et ARN à double brin (ARNds), et leurs procédés d'utilisations. En particulier, certains aspects de l'invention concerne des composés de formule (I), des compositions comprenant ceux-ci et des procédés d'utilisation associés, où n, Ar1, Ar2, X1, X2, X3, Z1 et Z2 sont ceux définis présentement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)