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1. (WO2012099755) PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/099755 International Application No.: PCT/US2012/020970
Publication Date: 26.07.2012 International Filing Date: 11.01.2012
IPC:
C07D 207/14 (2006.01) ,C07D 307/12 (2006.01) ,C08L 71/02 (2006.01) ,C12N 15/88 (2006.01) ,A61K 9/127 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
10
with substituted hydrocarbon radicals attached to ring carbon atoms
12
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
71
Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
02
Polyalkylene oxides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88
using micro-encapsulation, e.g. using liposome vesicle
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
RAJEEV, Kallanthottathil, G. [IN/US]; US (UsOnly)
MANOHARAN, Muthiah [US/US]; US (UsOnly)
JAYARAMAN, Muthusamy [IN/US]; US (UsOnly)
MAIER, Martin [DE/US]; US (UsOnly)
JAYAPRAKASH, Narayanannair, K. [IN/US]; US (UsOnly)
BUTLER, David [GB/US]; US (UsOnly)
ALNYLAM PHARMACEUTICALS, INC. [US/US]; 300 Third Street Cambridge, MA 02142, US (AllExceptUS)
Inventors:
RAJEEV, Kallanthottathil, G.; US
MANOHARAN, Muthiah; US
JAYARAMAN, Muthusamy; US
MAIER, Martin; US
JAYAPRAKASH, Narayanannair, K.; US
BUTLER, David; US
Agent:
LESSLER, Jay, R.; Blank Rome LLP The Chrysler Building 405 Lexington Ave. New York, NY 10174-0208, US
Priority Data:
61/431,68411.01.2011US
Title (EN) PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY
(FR) LIPIDES PÉGYLÉS ET LEUR UTILISATION POUR UNE ADMINISTRATION DE MÉDICAMENT
Abstract:
(EN) The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.
(FR) L'invention concerne des conjugués lipidiques pégylés pouvant être utilisés pour administrer des médicaments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)