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Pub. No.:    WO/2012/099540    International Application No.:    PCT/SG2012/000015
Publication Date: 26.07.2012 International Filing Date: 16.01.2012
C12N 15/09 (2006.01), C12N 15/113 (2010.01)
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way #20-10 Connexis Singapore 138632 (SG) (For All Designated States Except US).
WONG, Chee Furng [SG/SG]; (SG) (For US Only)
Inventors: WONG, Chee Furng; (SG)
Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088 Rochor Post Office Rochor Road Singapore 911833 (SG)
Priority Data:
61/433,291 17.01.2011 US
Abstract: front page image
(EN)The present invention relates to CMV promoter variants comprising one or more mutations corresponding to cytosine residues within CpG motifs. Said promoter variants are capable of driving strong and sustained heterologous gene expression in in vitro and in vivo applications such as gene therapy and recombinant protein expression.
(FR)La présente invention a pour objet des variants du promoteur du cytomégalovirus comprenant une ou plusieurs mutations correspondant à des résidus cytosine au sein de motifs CpG. Lesdits variants de promoteur permettent de commander une expression de gène hétérologue forte et prolongée dans des applications in vitro et in vivo telles que la thérapie génique et l'expression de protéines de recombinaison.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)