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1. (WO2012099452) CURCUMIN COMPOUNDS WITH SUPERIOR STRUCTURAL STABILITY AND PROCESSES FOR THEIR PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/099452    International Application No.:    PCT/MY2011/000175
Publication Date: 26.07.2012 International Filing Date: 22.07.2011
IPC:
C07D 487/10 (2006.01), A61K 31/407 (2006.01), A61P 25/28 (2006.01), A61P 31/00 (2006.01), A61P 31/06 (2006.01), A61P 31/18 (2006.01), C07D 487/20 (2006.01)
Applicants: UNIVERSITI SAINS MALAYSIA [MY/MY]; USM Pulau Pinang, 11800 (MY) (For All Designated States Except US).
ISMAIL, Rusli [MY/MY]; (MY) (For US Only).
ALI, Mohamed Ashraf [IN/MY]; (MY) (For US Only).
TAN, Soo Choon [MY/MY]; (MY) (For US Only).
AJMI, Noor Shahida [MY/MY]; (MY) (For US Only).
YEONG, Keng Yoon [MY/MY]; (MY) (For US Only).
SURESH KUMAR, Raju [IN/MY]; (MY) (For US Only).
OSMAN, Hasnah [MY/MY]; (MY) (For US Only)
Inventors: ISMAIL, Rusli; (MY).
ALI, Mohamed Ashraf; (MY).
TAN, Soo Choon; (MY).
AJMI, Noor Shahida; (MY).
YEONG, Keng Yoon; (MY).
SURESH KUMAR, Raju; (MY).
OSMAN, Hasnah; (MY)
Agent: NANJAPPAN, Puvaneswari; Kass International Sdn. Bhd. Suite 8-7-2, Menara Mutiara Bangsar, Jalan Liku Off Jalan Riong, Bangsar Kuala Lumpur, 59100 (MY)
Priority Data:
PI 2011000320 21.01.2011 MY
Title (EN) CURCUMIN COMPOUNDS WITH SUPERIOR STRUCTURAL STABILITY AND PROCESSES FOR THEIR PREPARATION
(FR) COMPOSÉS DE CURCUMINE AYANT UNE STABILITÉ STRUCTURALE SUPÉRIEURE ET PROCÉDÉS POUR LEUR PRÉPARATION
Abstract: front page image
(EN)Accordingly, the invention discloses compounds with enhanced bioavailability for the prevention and treatment of anti-human immunodeficiency virus (HIV), anti-tuberculosis (TB), anti-Alzheimer or anti-cancer. The invention also discloses the method in synthesizing these compounds wherein the steps includes mixing curcumin, isatin derivatives or ninhydrin and proline in 20 mL methanol. The mixture was then refluxed with a solvent on a water bath and excess solvent was removed under vacuum. The residue subjected to flash column chromatography using petroleum ether: ethyl acetate mixture (4:1) as eluent to afford the product. The ratio for curcumin: isatin derivative/ninhydrin:proline is 1 :1 :2 and 1 :2:4.
(FR)La présente invention concerne des composés ayant une biodisponibilité augmentée pour la prévention et le traitement anti-virus d'immunodéficience humaine (VIH), anti-tuberculose (TB), anti-Alzheimer ou anticancéreux. L'invention concerne en outre le procédé de synthèse de ces composés dans lequel les étapes comprennent le mélange de curcumine, de dérivés d'isatine ou de ninhydrine et de proline dans 20 ml de méthanol. Le mélange est ensuite chauffé à reflux avec un solvant sur un bain-marie et l'excès de solvant est éliminé sous vide. Le résidu est soumis à chromatographie sur colonne flash en utilisant un mélange d'éther de pétrole : acétate d'éthyle (4:1) en tant qu'éluant pour obtenir le produit. Le rapport pour curcumine : dérivé d'isatine/ninhydrine : proline est 1:1:2 et 1:2:4.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)