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1. (WO2012099448) RECOMBINANT ADENOVIRUS EXPRESSING αA-CRYSTALLIN GENE AND GENE THERAPY FOR RETINAL VASCULAR DISEASE USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/099448    International Application No.:    PCT/KR2012/000580
Publication Date: 26.07.2012 International Filing Date: 20.01.2012
IPC:
C12N 7/01 (2006.01), C12N 15/861 (2006.01), A61K 35/76 (2006.01), A61P 27/02 (2006.01)
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY [KR/KR]; Jinju-daero 501, Gajwa-dong Jinju-si, Gyeongsangnam-do 660-701 (KR) (For All Designated States Except US).
CHOI, Wan Sung [KR/KR]; (KR) (For US Only).
WHANG, Eun Mi [KR/KR]; (KR) (For US Only).
PARK, Jae Yong [KR/KR]; (KR) (For US Only).
CHO, Gyeong Jae [KR/KR]; (KR) (For US Only).
KIM, Young Hee [KR/KR]; (KR) (For US Only).
PARK, So Yun [KR/KR]; (KR) (For US Only)
Inventors: CHOI, Wan Sung; (KR).
WHANG, Eun Mi; (KR).
PARK, Jae Yong; (KR).
CHO, Gyeong Jae; (KR).
KIM, Young Hee; (KR).
PARK, So Yun; (KR)
Agent: SON, Min; Hanol Intellectual Property & Law 6th Floor, City Air Tower 36, Teheran-ro 87 gil Samsung-dong Gangnam-gu Seoul 135-973 (KR)
Priority Data:
10-2011-0006447 21.01.2011 KR
Title (EN) RECOMBINANT ADENOVIRUS EXPRESSING αA-CRYSTALLIN GENE AND GENE THERAPY FOR RETINAL VASCULAR DISEASE USING SAME
(FR) ADÉNOVIRUS RECOMBINANT EXPRIMANT LE GÈNE ΑA-CRISTALLIN ET THÉRAPIE GÉNIQUE DE LA RÉTINOPATHIE VASCULAIRE L'UTILISANT
(KO) αΑ-크리스탈린 유전자를 발현하는 재조합 아데노바이러스 및 이를 이용한 망막혈관 질환의 유전자 치료
Abstract: front page image
(EN)The present invention relates to recombinant adenovirus expressing αA-crystallin gene and to a gene therapy for retinal vascular disease using the recombinant adenovirus. The gene therapy using the recombinant adenovirus including αA-crystallin gene according to the present invention increases the expression level of αA-crystallin gene in injured of retinal pericytes to inhibit apoptosis and loss of pericytes, retinal vascular leakage, and leukocyte adherence in peripheral retinal vessels so as to protect pericytes. Therefore, the gene therapy using the recombinant adenovirus including αA-crystallin gene according to the present invention may be valuably used in the prevention and treatment of various retinal vascular diseases such as diabetic retinopathy.
(FR)Cette invention concerne un adénovirus recombinant exprimant le gène αA-cristallin et la thérapie génique de la rétinopathie vasculaire l'utilisant. La thérapie génique faisant appel à l'adénovirus recombinant contenant le gène αA-cristallin selon cette invention augmente le niveau d'expression du gène αA-cristallin dans les péricytes rétiniens lésés pour inhiber l'apoptose et la perte de péricytes, la fuite vasculaire rétinienne, et l'adhérence leucocytaire dans les vaisseaux rétiniens périphériques de manière à protéger les péricytes. Par conséquent, la thérapie génique faisant appel à l'adénovirus recombinant contenant le gène αA-cristallin selon cette invention peut être utilisée de manière avantageuse pour prévenir et traiter diverses rétinopathies vasculaires telles que la rétinopathie diabétique.
(KO)본 발명은 αA-크리스탈린(αA-crystallin) 유전자를 발현하는 재조합 아데노바이러스 및 상기 재조합 아데노바이러스를 이용한 망막혈관 질환의 유전자 치료에 관한 것이다. 본 발명의 αA-크리스탈린 유전자를 포함하는 재조합 아데노바이러스를 이용한 유전자 치료는 손상된 망막 주위세포에서 αA-크리스탈린 유전자의 발현 수준을 증가시켜 혈관 주위세포의 사멸 및 손실을 억제하고, 망막혈관의 누출을 억제하며, 망막혈관 주변의 백혈구 점착을 억제하여 혈관 주위세포를 보호함으로써 당뇨 망막병증을 비롯한 다양한 망막혈관 질환의 예방 및 치료에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)