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1. (WO2012098645) METHOD FOR PRODUCTION OF MODEL ANIMAL FOR MENTAL DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/098645    International Application No.:    PCT/JP2011/050757
Publication Date: 26.07.2012 International Filing Date: 18.01.2011
IPC:
A01K 67/027 (2006.01), A61P 25/00 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES [JP/JP]; 4-9-1, Anagawa, Inage-ku, Chiba-shi Chiba 2638555 (JP) (For All Designated States Except US).
A SCHOOL JURIDICAL PERSON FUJITA EDUCATIONAL INSTITUTION [JP/JP]; 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi Aichi 4701192 (JP) (For All Designated States Except US).
OH-NISHI Arata [JP/JP]; (JP) (For US Only).
MINAMIMOTO Takafumi [JP/JP]; (JP) (For US Only).
NAGAI Yuji [JP/JP]; (JP) (For US Only).
SUHARA Tetsuya [JP/JP]; (JP) (For US Only).
MIYAKAWA Tsuyoshi [JP/JP]; (JP) (For US Only).
HAGIHARA Hideo [JP/JP]; (JP) (For US Only)
Inventors: OH-NISHI Arata; (JP).
MINAMIMOTO Takafumi; (JP).
NAGAI Yuji; (JP).
SUHARA Tetsuya; (JP).
MIYAKAWA Tsuyoshi; (JP).
HAGIHARA Hideo; (JP)
Agent: ISHIKAWA Toru; ORION I.P.O., Fuji Bldg. 2nd. Floor, 24-12, Kanumadai, 2-Chome, Chuo-ku, Sagamihara-Shi Kanagawa 2520233 (JP)
Priority Data:
Title (EN) METHOD FOR PRODUCTION OF MODEL ANIMAL FOR MENTAL DISEASES
(FR) PROCÉDÉ DE PRODUCTION D'UN ANIMAL MODÈLE POUR LES MALADIES MENTALES
(JA) 精神病モデル動物の作成方法
Abstract: front page image
(EN)The purpose of the present invention is to provide a method for producing a model animal for mental diseases using a non-human primate. The present invention provides a method for producing a model animal for mental diseases using a non-human primate, which comprises the following steps: (a) a step of preparing a pregnant non-human primate; (b) a step of activating immunity of the primate during the organ development stage of a fetus of the primate; and (c) a step of allowing the primate to get birth. A born offspring is a model animal for mental diseases. The present invention also provides a model animal for metal diseases, which is produced by the method. The present invention further provides a method for screening for an anti-mental-disease agent using a model animal for mental diseases which is produced by the method.
(FR)La présente invention concerne un procédé de production d'un animal modèle pour les maladies mentales en utilisant un primate non humain. Le procédé selon la présente invention comporte les étapes suivantes : (a) une étape consistant à préparer un primate non humain gravide ; (b) une étape consistant à activer l'immunité du primate pendant le stade de développement des organes d'un fœtus du primate ; et (c) une étape consistant à permettre au primate de donner naissance. La progéniture qui en est née constitue un animal modèle pour les maladies mentales. La présente invention concerne également un animal modèle pour les maladies mentales, qui est produit par ledit procédé. La présente invention concerne en outre un procédé de dépistage d'un agent anti-maladies mentales en utilisant un animal modèle pour les maladies mentales produit par le procédé.
(JA) 本発明は、非ヒト霊長類を用いる、精神病モデル動物の作成方法を提供することを目的とする。 本発明は、下記工程を含む、非ヒト霊長類を用いる精神病モデル動物の作成方法を提供する:(a) 妊娠した非ヒト霊長類を提供する工程;(b) 該霊長類の胎児の器官形成期に、該霊長類の免疫を活性化させる工程;及び(c) 出産させる工程である。出生した子が、精神病モデル動物となる。また、本発明は、当該方法により作成された精神病モデル動物を提供する。さらに、本発明は、当該方法により作成した精神病モデル動物を用いた、抗精神病薬のスクリーニング方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)