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1. (WO2012098557) PEGYLATED GEMCITABINE DERIVATIVE AND PROCESS FOR PREPARING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/098557    International Application No.:    PCT/IN2011/000214
Publication Date: 26.07.2012 International Filing Date: 29.03.2011
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01), A61K 31/7068 (2006.01)
Applicants: INSTITUTE OF LIFE SCIENCES [IN/IN]; Nano Medicine Laboratory Nalco Square Chandrasekharpur Bhubaneswar Orissa 751 923 (IN) (For All Designated States Except US).
SAHOO, Sanjeeb, Kumar [IN/IN]; (IN) (For US Only).
VANDANA, Mallaredy [IN/IN]; (IN) (For US Only)
Inventors: SAHOO, Sanjeeb, Kumar; (IN).
VANDANA, Mallaredy; (IN)
Agent: DAVAR, G., S.; L.S. Davar & Co. 32 Radha Madhav Dutta Garden Lane Kolkata 700 010 West Bengal (IN)
Priority Data:
77/KOL/2011 20.01.2011 IN
Title (EN) PEGYLATED GEMCITABINE DERIVATIVE AND PROCESS FOR PREPARING THE SAME
(FR) DÉRIVÉ PEGYLÉ DE GEMCITABINE ET SON PROCÉDÉ DE PRÉPARATION
Abstract: front page image
(EN)According to this invention, a water soluble polymeric drug formulation is provided comprising the amphiphilic polymer conjugated to the amino group of gemcitabine. In accordance with this invention there is also provided a process for the preparation of water soluble polymeric drug formulation comprising the steps of: (a) providing an N-hydroxysuccinirnide ester of PEG by reaction of the carboxyl group of PEG with NHS in presence of EDC as a catalyst; (b) conjugation of the said polymer with the amine group of the gemcitabine.
(FR)L'invention concerne une formulation de médicament polymère hydrosoluble comprenant le polymère amphiphile conjugué au groupe amino de la gemcitabine. L'invention concerne également un procédé de préparation d'une formulation de médicament polymère hydrosoluble comprenant les étapes de : (a) apport d'un ester N-hydroxysuccinidique de PEG par la réaction du groupe carboxyle de PEG avec le N-hydroxysuccinimide (NHS) en présence d'EDC en tant que catalyseur ; (b) conjugaison dudit polymère avec le groupe amino de la gemcitabine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)