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1. (WO2012098066) 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/098066    International Application No.:    PCT/EP2012/050541
Publication Date: 26.07.2012 International Filing Date: 16.01.2012
IPC:
C07D 471/04 (2006.01), A61K 31/4375 (2006.01), A61P 35/00 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
LUK, Kin-Chun Thomas [US/US]; (US) (For US Only)
Inventors: LUK, Kin-Chun Thomas; (US)
Agent: SALUD, Carlos; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
61/433,999 19.01.2011 US
Title (EN) 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS
(FR) 1,6- ET 1,8-NAPHTHYRIDINES UTILES EN TANT QU'INHIBITEURS DE DYRK1
Abstract: front page image
(EN)Compounds of formula I, and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
(FR)L'invention concerne des composés de formule I, et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que les compositions pharmaceutiques contenant lesdits composés et leurs sels pharmaceutiquement acceptables, et l'utilisation desdits composés et compositions pharmaceutiques pour le traitement, la gestion ou l'amélioration de maladies prolifératives, notamment le cancer, le syndrome de Down ou la maladie d'Alzheimer à apparition précoce.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)