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1. (WO2012098048) PROCESS FOR THE PREPARATION OF DIOL SULFONES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/098048    International Application No.:    PCT/EP2012/050468
Publication Date: 26.07.2012 International Filing Date: 13.01.2012
IPC:
C07D 413/12 (2006.01), C07D 419/12 (2006.01)
Applicants: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. [NL/NL]; P.O.Box 245 Alexander Fleminglaan 1 NL-2613 AX Delft (NL) (For All Designated States Except US).
DE LANGE, Ben [NL/NL]; (NL) (For US Only).
RIEBEL, Peter, Hans [DE/NL]; (NL) (For US Only).
WOLBERG, Michael [DE/NL]; (NL) (For US Only).
HEEMSKERK, Dennis [NL/NL]; (NL) (For US Only).
MINK, Daniel [BE/NL]; (NL) (For US Only)
Inventors: DE LANGE, Ben; (NL).
RIEBEL, Peter, Hans; (NL).
WOLBERG, Michael; (NL).
HEEMSKERK, Dennis; (NL).
MINK, Daniel; (NL)
Agent: DE VROOM, Erik; DSM Intellectual Property P.O. Box 130 NL-6100 AC Echt (NL)
Priority Data:
11151280.2 18.01.2011 EP
Title (EN) PROCESS FOR THE PREPARATION OF DIOL SULFONES
(FR) PROCÉDÉ POUR LA PRÉPARATION DE SULFONES DE DIOL
Abstract: front page image
(EN)The present invention relates to a process for the preparation of a diol sulfone derivative comprising reaction of a halomethyl substrate with a thio-aryl compound to obtain a thio-ether compound, and oxidizing the thio-ether compound to the corresponding sulfone. In case of a chiral halomethyl substrate, the resulting chiral diol sulfone derivative is suitable as a building block for statin type compounds.
(FR)La présente invention porte sur un procédé pour la préparation d'un dérivé sulfone de diol comprenant la réaction d'un substrat à halogénométhyle avec un composé thioaryle pour obtenir un composé thioéther et l'oxydation du composé thioéther en la sulfone correspondante. Dans le cas d'un substrat à halogénométhyle chiral, le dérivé sulfone de diol chiral ainsi obtenu est approprié comme molécule élémentaire pour des composés de type statine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)