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1. (WO2012098006) COMPOUNDS AND METHODS FOR THE IDENTIFICATION AND CHARACTERIZATION OF HDAC INTERACTING COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/098006    International Application No.:    PCT/EP2012/000259
Publication Date: 26.07.2012 International Filing Date: 20.01.2012
IPC:
C12Q 1/34 (2006.01), G01N 33/68 (2006.01), C07C 259/00 (2006.01)
Applicants: CELLZOME GMBH [DE/DE]; Meyershofstr. 1 69117 Heidelberg (DE) (For All Designated States Except US).
RAMSDEN, Nigel [GB/GB]; (GB) (For US Only).
READER, Valerie [FR/GB]; (GB) (For US Only)
Inventors: RAMSDEN, Nigel; (GB).
READER, Valerie; (GB)
Agent: POVEY, Alexander William; GlaxoSmithKline Global Patents CN925.1 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Priority Data:
11000501.4 21.01.2011 EP
Title (EN) COMPOUNDS AND METHODS FOR THE IDENTIFICATION AND CHARACTERIZATION OF HDAC INTERACTING COMPOUNDS
(FR) COMPOSÉS ET PROCÉDÉS POUR L'IDENTIFICATION ET LA CARACTÉRISATION DE COMPOSÉS INTERAGISSANT AVEC L'HDAC
Abstract: front page image
(EN)The present invention relates to methods for the identification of HD AC interacting compounds using the ligand having the structure wherein R is H, C1-C6 alkyl, or cycloalkyl and X is a C1-C6 alkyl, cycloalkyl or an aryl, wherein the ligand is immobilized on a solid support via the NHR-group as well as to compounds having said structures.
(FR)L'invention concerne des procédés permettant l'identification de composés interagissant avec HDAC en utilisant le ligand ayant la structure dans laquelle R représente H, un C1-C6 alkyle, ou un cycloalkyle et X représente un C1-C6 alkyle, un cycloalkyle ou un aryle, le ligand étant immobilisé sur un support solide par le biais du groupe NHR; elle concerne également des composés ayant lesdites structures.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)