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Pub. No.:    WO/2012/097435    International Application No.:    PCT/CA2012/000031
Publication Date: 26.07.2012 International Filing Date: 13.01.2012
C40B 40/10 (2006.01), C07K 14/195 (2006.01), C40B 30/04 (2006.01), G01N 33/543 (2006.01), G01N 33/569 (2006.01)
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA [CA/CA]; 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA) (For All Designated States Except US).
TWINE, Susan [CA/CA]; (CA) (For US Only).
CONLAN, Joseph Wayne [CA/CA]; (CA) (For US Only)
Inventors: TWINE, Susan; (CA).
CONLAN, Joseph Wayne; (CA)
Agent: ECKENSWILLER, Laura Catherine; National Research Council of Canada IP Portfolio Management 1200 Montreal Road Ottawa, Ontario K1A 0R6 (CA)
Priority Data:
61/433,385 17.01.2011 US
Abstract: front page image
(EN)The present invention provides sets of biomarkers for tularaemia comprising one or more proteins selected from the group consisting of: dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 50S ribosomal protein L7/L12, 30S ribosomal protein S1, DNA-directed RNA polymerase alpha subunit, Acetyl-CoA carboxylase, Outer membrane associated protein FopA, Peroxidase/catalase, Chaperone protein DnaK, Pyruvate dehydrogenase E2 component, Chaperone protein groEL, Hypothetical membrane protein, and any combination thereof, and their use as correlates of protection and for evaluating vaccine efficacy.
(FR)L'invention concerne des ensembles de biomarqueurs de la tularémie, qui comprennent une ou plusieurs protéines sélectionnées dans le groupe constitué par: un composant de la dihydrolipoamide succinyltransférase du complexe 2-oxoglutarate déshydrogénase, la protéine ribosomale 50S L7/L12, la protéine ribosomale 30S S1, une sous-unité alpha d'ARN polymérase ADN dépendante, l'acétyl-CoA carboxylase, la protéine de membrane externe FopA, la peroxidase/catalase, la protéine chaperon DnaK, un composant de la pyruvate déshydrogénase E2, la protéine chaperon groEL, une protéine membranaire hypothétique et toute combinaison de ces protéines. L'invention concerne aussi l'utilisation de ces protéines comme corrélats de protection et pour évaluer l'efficacité d'un vaccin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)