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1. (WO2012097313) THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/097313    International Application No.:    PCT/US2012/021339
Publication Date: 19.07.2012 International Filing Date: 13.01.2012
IPC:
C07K 16/28 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 (US) (For All Designated States Except US).
KIPPS, Thomas, J. [US/US]; (US) (For US Only).
WIDHOPF II, George, F. [US/US]; (US) (For US Only).
CUI, Bing [CN/US]; (US) (For US Only)
Inventors: KIPPS, Thomas, J.; (US).
WIDHOPF II, George, F.; (US).
CUI, Bing; (US)
Agent: TAYLOR, Stacy, L.; DLA PIPER LLP (US) 4365 Executive Drive, Suite 1100 San Diego, CA 92121-2133 (US)
Priority Data:
61/433,043 14.01.2011 US
Title (EN) THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND METHODS FOR USE OF SAME
(FR) ANTICORPS THÉRAPEUTIQUES CONTRE LA PROTÉINE ROR-1 ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN)Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
(FR)La présente invention a pour objet des anticorps thérapeutiques ayant une spécificité de liaison pour ROR-1 exprimée sur des cellules cancéreuses (en particulier des cellules leucémiques et lymphomateuses) et des compositions pharmaceutiques contenant un ou plusieurs de ces anticorps destinées à être utilisées dans le traitement du cancer. La présente invention concerne aussi des méthodes de diagnostic de tels cancers par la détection in vitro de la liaison à la protéine ROR-1 exprimée sur des cellules cancéreuses putatives.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)