WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012097196) PYRAZOLOPYRIMIDINE DERIVATIVES AND USES AS ANTICANCER AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/097196    International Application No.:    PCT/US2012/021144
Publication Date: 19.07.2012 International Filing Date: 12.01.2012
IPC:
C07D 487/04 (2006.01), A61K 31/519 (2006.01), A61P 35/00 (2006.01)
Applicants: ACEA BIOSCIENCES INC. [US/US]; 6779 Mesa Ridge Rd, Suite 100 San Diego, CA 92121 (US) (For All Designated States Except US).
MAO, Long [US/US]; (US) (For US Only).
ZHAO, Li [CN/US]; (US) (For US Only).
LIU, Jia [US/US]; (US) (For US Only).
WANG, Xiaobo [US/US]; (US) (For US Only).
XU, Xiao [US/US]; (US) (For US Only)
Inventors: MAO, Long; (US).
ZHAO, Li; (US).
LIU, Jia; (US).
WANG, Xiaobo; (US).
XU, Xiao; (US)
Agent: AKHOON, Kauser, M.; Morrison & Foerster LLP 12531 High Bluff Drive, Suite 100 San Diego, CA 92130-2040 (US)
Priority Data:
61/432,164 12.01.2011 US
Title (EN) PYRAZOLOPYRIMIDINE DERIVATIVES AND USES AS ANTICANCER AGENTS
(FR) DÉRIVÉS DE PYRAZOLOPYRIMIDINE ET LEURS UTILISATIONS COMME AGENTS ANTICANCÉREUX
Abstract: front page image
(EN)Novel compounds having a fused pyrazolopyrimidine derivatives and related fused ring systems are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Pharmaceutical compositions, and methods of using these compounds and compositions to treat cancer and other diseases related to the dysregulation of kinase (such as Aurora A, Aurora B, Aurora C, cMet, JAK2, ROS1, but not limited to) pathways are disclosed. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
(FR)L'invention concerne de nouveaux composés comprenant des dérivés de pyrazolopyrimidine fusionnés et des systèmes cycliques fusionnés apparentés. Lesdits composés inhibent le développement de divers types de cellules cancéreuses et peuvent donc être utilisés pour le traitement du cancer. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés et compositions pour traiter le cancer et d'autres maladies liées à une mauvaise régulation des voies des kinases (par exemple Aurora A, Aurora B, Aurora C, cMet, JAK2, ROS1). L'efficacité de ces composés est démontrée par un système de suivi du développement/de la migration des cellules, qui montre qu'il s'agit de puissants inhibiteurs du développement et/ou de la migration des cellules cancéreuses. L'invention concerne, en outre, des compositions comprenant ces composés et des méthodes d'utilisation de ces composés et compositions pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)