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Machine translation
1. (WO2012097155) IMPROVED PHARMACEUTICAL COMPOSITIONS FOR DELIVERY OF FERRIC IRON COMPOUNDS, AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/097155    International Application No.:    PCT/US2012/021083
Publication Date: 19.07.2012 International Filing Date: 12.01.2012
IPC:
A61K 33/26 (2006.01), A61K 31/295 (2006.01)
Applicants: CHIASMA INC. [US/US]; 831 Beacon Street, Suite 313 Newton Centre, MA 02459 (US) (For All Designated States Except US).
TUVIA, Shmuel [IL/IL]; (IL) (For US Only).
GELBAUM, Dana [IL/IL]; (IL) (For US Only).
SALAMA, Paul [IL/IL]; (IL) (For US Only).
KARMELI, Irina [IL/IL]; (IL) (For US Only).
PELLED, Dori [IL/IL]; (IL) (For US Only)
Inventors: TUVIA, Shmuel; (IL).
GELBAUM, Dana; (IL).
SALAMA, Paul; (IL).
KARMELI, Irina; (IL).
PELLED, Dori; (IL)
Agent: MCCARTY, Catherine, M.; Lando & Anastasi LLP Riverfront Office Park One Main Street, Suite 1100 Cambridge, MA 02142 (US)
Priority Data:
61/432,790 14.01.2011 US
61/537,364 21.09.2011 US
Title (EN) IMPROVED PHARMACEUTICAL COMPOSITIONS FOR DELIVERY OF FERRIC IRON COMPOUNDS, AND METHODS OF USE THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES AMÉLIORÉES UTILISABLES EN VUE DE L'ADMINISTRATION DE COMPOSÉS DE FER FERRIQUE ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The pharmaceutical compositions described comprise a therapeutically effective amount of a ferric compound and at least one bioavailability enhancer for oral delivery. Some pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a ferric compound and at least one bioavailability enhancer (e.g. a salt of a medium chain fatty acid) and a lipophilic medium. The pharmaceutical compositions may be enteric-coated. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed. The methods of treatment described herein increase the level of iron in the bloodstream of a subject by administering to the subject an effective amount of an oral composition of a ferric iron compound.
(FR)L'invention concerne des compositions pharmaceutiques pour administration orale qui comprennent une quantité thérapeutiquement efficace d'un composé ferrique et au moins un activateur de la biodisponibilité. Certaines compositions pharmaceutiques de l'invention comprennent une suspension comportant un mélange, se présentant sous forme solide, associant une quantité thérapeutiquement efficace d'un composé ferrique, au moins un activateur de la biodisponibilité (par exemple, un sel d'un acide gras à chaîne moyenne) et un milieu lipophile. Les compositions pharmaceutiques peuvent comprendre un enrobage entérique. L'invention concerne également des méthodes de traitement ou de prévention de maladies impliquant l'administration desdites compositions à des sujets affectés. Les méthodes de traitement de l'invention augmentent le niveau de fer dans la circulation sanguine d'un sujet suite à l'administration audit sujet d'une quantité efficace d'une composition orale d'un composé de fer ferrique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)