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1. (WO2012097069) BIOMARKERS FOR RECURRENCE PREDICTION OF COLORECTAL CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/097069    International Application No.:    PCT/US2012/020949
Publication Date: 19.07.2012 International Filing Date: 11.01.2012
IPC:
G01N 33/574 (2006.01)
Applicants: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE; No. 195, Sec. 4, Chung Hsing Rd., Chutung Hsinchu, 31040 (TW) (For All Designated States Except US).
WANG, Ting-Huei; (TW) (For US Only).
LI, Yen-Peng; (TW) (For US Only).
KUO, Pei-Fen; (TW) (For US Only).
CHEN, Shih-Ya; (TW) (For US Only).
LIN, Chia-Ju; (TW) (For US Only).
LEE, Jenq-Chang; (TW) (For US Only).
LEE, Angelina Huai-Lo [US/--]; (TW) (For US Only)
Inventors: WANG, Ting-Huei; (TW).
LI, Yen-Peng; (TW).
KUO, Pei-Fen; (TW).
CHEN, Shih-Ya; (TW).
LIN, Chia-Ju; (TW).
LEE, Jenq-Chang; (TW).
LEE, Angelina Huai-Lo; (TW)
Agent: MCROBBIE, Craig A.; c/o Birch, Stewart, Kolasch & Birch, LLP P.O. Box 747 Falls Church, Virginia 22040-0747 (US)
Priority Data:
61/432,468 13.01.2011 US
13/348,098 11.01.2012 US
Title (EN) BIOMARKERS FOR RECURRENCE PREDICTION OF COLORECTAL CANCER
(FR) BIOMARQUEURS POUR LA PRÉDICTION DE RÉCURRENCE DU CANCER COLORECTAL
Abstract: front page image
(EN)Methods for determining the likelihood of colorectal cancer (CRC) recurrence in a subject that involve measuring the expression level of two or more micro ribonucleic acids (miRNAs) in a biological sample comprising CRC tumor cells from said subject and using the normalized, measured expression levels to determine the likelihood of colorectal cancer recurrence for said subject. In the methods, the normalized expression levels of specific miRNAs are weighted by their contribution to CRC recurrence to calculate the likelihood of CRC recurrence. Kits for measuring the expression level of specific miRNAs that can be used in determining the likelihood of CRC recurrence are also provided.
(FR)L'invention concerne des procédés permettant de déterminer la probabilité d'une récurrence du cancer colorectal (CRC) chez un sujet, lesquels consistent à mesurer le niveau d'expression de deux micro-acides ribonucléiques ou plus (miARN) dans un échantillon biologique comprenant des cellules tumorales de CRC issues dudit sujet, et à utiliser les niveaux d'expression mesurés et normalisés afin de déterminer la probabilité d'une récurrence du cancer colorectal pour ledit sujet. Dans ces procédés, les niveaux d'expression normalisés de miARN spécifiques sont pondérés par leur contribution à la récurrence du CRC afin de calculer la probabilité de récurrence du CRC. L'invention concerne également des kits pour mesurer le niveau d'expression de miARN spécifiques qui peuvent être utilisés afin de déterminer la probabilité d'une récurrence du CRC.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)