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1. (WO2012095707) PROCESS FOR THE PREPARATION OF NEBIVOLOL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/095707    International Application No.:    PCT/IB2011/055385
Publication Date: 19.07.2012 International Filing Date: 30.11.2011
Chapter 2 Demand Filed:    28.09.2012    
IPC:
C07D 311/58 (2006.01)
Applicants: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. [LU/LU]; 1, Avenue de la Gare L-1611 Luxembourg (LU) (For All Designated States Except US).
MAURO, Sandro [IT/IT]; (IT) (For US Only).
FATTORI, Daniela [IT/IT]; (IT) (For US Only).
CIPOLLONE, Amalia [IT/IT]; (IT) (For US Only).
D'ANDREA, Piero [IT/IT]; (IT) (For US Only)
Inventors: MAURO, Sandro; (IT).
FATTORI, Daniela; (IT).
CIPOLLONE, Amalia; (IT).
D'ANDREA, Piero; (IT)
Agent: GERMINARIO, Claudio; Società Italiana Brevetti S.p.A. Piazza di Pietra 39 I-00186 Roma (IT)
Priority Data:
RM2010A000622 30.11.2010 IT
Title (EN) PROCESS FOR THE PREPARATION OF NEBIVOLOL
(FR) PROCÉDÉ DE PRÉPARATION DE NÉBIVOLOL
Abstract: front page image
(EN)The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
(FR)La présente invention concerne un nouveau procédé pour la synthèse du produit Nébivolol réprésenté dans le Schéma 1. Ce procédé comprend un nombre réduit d'étapes à haut rendement et est caractérisé par la résolution enzymatique du précurseur ester de chromane.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Italian (IT)