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1. (WO2012095527) METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/095527 International Application No.: PCT/EP2012/050513
Publication Date: 19.07.2012 International Filing Date: 13.01.2012
IPC:
A61K 47/48 (2006.01) ,C07K 14/435 (2006.01) ,C12N 15/62 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants:
VILLAVERDE CORRALES, Antonio [ES/ES]; ES (UsOnly)
VÁZQUEZ GÓMEZ, Esther [ES/ES]; ES (UsOnly)
CÉSPEDES NAVARRO, María Virtudes [ES/ES]; ES (UsOnly)
CASANOVA RIGAT, Isolda [ES/ES]; ES (UsOnly)
FERRER MIRALLES, Neus [ES/ES]; ES (UsOnly)
MANGUES BAFALLUY, Ramon [ES/ES]; ES (UsOnly)
UNZUETA ELORZA, Ugutz [ES/ES]; ES (UsOnly)
UNIVERSITAT AUTONOMA DE BARCELONA [ES/ES]; Edifici A Campus universitari s/n E-08193 Bellaterra (Cerdanyola del Valles), ES (AllExceptUS)
INSTITUT RECERCA HOSPITAL DE LA SANTA CREU I SANT PAU [ES/ES]; Hospital de Sant Pau C/Sant Antoni Maria Claret 167 E-08025 Barcelona, ES (AllExceptUS)
CENTRO INVESTIGACIÓN BIOMÉDICA EN RED (CIBER BBN) [ES/ES]; Edificio I+D Campus Río Ebro - Edificio I+D - Pta. 1ª, Bloq. 5 C/Poeta Mariano Esquillor, s/n E-50018 Zaragoza, ES (AllExceptUS)
Inventors:
VILLAVERDE CORRALES, Antonio; ES
VÁZQUEZ GÓMEZ, Esther; ES
CÉSPEDES NAVARRO, María Virtudes; ES
CASANOVA RIGAT, Isolda; ES
FERRER MIRALLES, Neus; ES
MANGUES BAFALLUY, Ramon; ES
UNZUETA ELORZA, Ugutz; ES
Priority Data:
11382005.413.01.2011EP
Title (EN) METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS
(FR) PROCÉDÉS ET RÉACTIFS POUR LA LIVRAISON EFFICACE ET CIBLÉE DE MOLÉCULES THÉRAPEUTIQUES AUX CELLULES CXCR4
Abstract:
(EN) The invention relates to conjugates comprising a targeting moiety specific for the CXCR4 based on the polyphemusin-derived peptide and a therapeutic or imaging agent. The invention relates as well to the application of said conjugates for the therapy and diagnostics which require the specific targeting to CXCR4+ cells.
(FR) L'invention concerne des conjugués comprenant une partie ciblante spécifique des CXCR4 basée sur un peptide dérivé de la polyphémusine et un agent thérapeutique ou d'imagerie. L'invention concerne aussi l'application desdits conjugués pour le traitement et les diagnostics qui nécessitent le ciblage spécifique des cellules CXCR4+.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)