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1. (WO2012094540) METHODS FOR PREPARATION OF GLYCOSPHINGOLIPIDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/094540    International Application No.:    PCT/US2012/020388
Publication Date: 12.07.2012 International Filing Date: 05.01.2012
IPC:
C07H 15/06 (2006.01), A61K 39/39 (2006.01), C07H 15/04 (2006.01), C07H 15/18 (2006.01), A61P 31/04 (2006.01), A61P 31/12 (2006.01), A61P 35/00 (2006.01)
Applicants: LIANG, Pi-Hui [--/US]; (US) (For US Only).
NATIONAL TAIWAN UNIVERSITY; No. 1, Sec. 4, Roosevelt Road Taipei, 10617 (TW) (For All Designated States Except US)
Inventors: LIANG, Pi-Hui; (US)
Agent: BASU, Shantanu; Eckman Basu LLP 2225 E Bayshore Road Suite 200 Palo Alto, California 94304 (US)
Priority Data:
61/430,117 05.01.2011 US
Title (EN) METHODS FOR PREPARATION OF GLYCOSPHINGOLIPIDS AND USES THEREOF
(FR) PROCÉDÉS POUR LA PRÉPARATION DE GLYCOSPHINGOLIPIDES ET UTILISATIONS DE CEUX-CI
Abstract: front page image
(EN)Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of a-galactosyl ceramides, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells. A process for preparing a chiral compound comprising an R-form or S- form of a glycosphingolipid of formula (1 ) is provided, wherein R1=OH, NH2, NHCOR2, R2 = H or an alkyl, alkenyl, or alkyl terminating in aryl, substituted aryl, heteroaryl, or substituted heteroaryl, X=alkyl group, R3= OH or H, R4=OH or H, R5= aryl, substituted aryl, heteroaryl, or substituted heteroaryl, or a pharmaceutically acceptable salt thereof, wherein the compound of formula 1 is prepared by (a) deprotecting a compound of formula (2): wherein PG is a hydroxyl protecting group, with hydrogen under hydrogenation catalysis.
(FR)L'invention concerne des procédés pour la synthèse et la préparation d'alpha-glycosphingolipides. L'invention concerne des procédés pour la synthèse de α-galactosylcéramide, et d'analogues et variants pharmaceutiquement actifs de celui-ci. L'invention concerne également de nouveaux alpha-glycosphingolipides, où les composés sont des composés immunogènes qui servent de ligands pour les cellules NKT (T tueuses naturelles).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)