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1. (WO2012094313) PYRAZOLE DERIVATIVES AS ERK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/094313    International Application No.:    PCT/US2012/020074
Publication Date: 12.07.2012 International Filing Date: 03.01.2012
IPC:
C07D 471/04 (2006.01), C07D 403/04 (2006.01), A61K 31/4745 (2006.01), A61P 35/00 (2006.01), A61P 29/00 (2006.01)
Applicants: KINENTIA BIOSCIENCES LLC [US/US]; 9 University Place Rensselaer, New York 12144 (US) (For All Designated States Except US).
FAIRFAX, David [GB/US]; (US) (For US Only).
DEORAZIO, Russell Joseph [US/US]; (US) (For US Only)
Inventors: FAIRFAX, David; (US).
DEORAZIO, Russell Joseph; (US)
Agent: FREDERICKS, Kellie S.; Heslin Rothenberg Farley & Mesiti P.C. 5 Columbia Circle Albany, New York 12203 (US)
Priority Data:
61/429,497 04.01.2011 US
Title (EN) PYRAZOLE DERIVATIVES AS ERK INHIBITORS
(FR) DÉRIVÉS DE PYRAZOLE À TITRE D'INHIBITEURS D'ERK
Abstract: front page image
(EN)This invention describes substituted pyrazole derivatives of Formula I, and methods of making and using the compounds. These compounds have utility in the treatment of conditions or diseases in which modification of the activity of ERK would have a positive therapeutic outcome, for instance various cancers, psoriasis and actinic keratosis.
(FR)Cette invention concerne des dérivés de pyrazole substitués de Formule I, et des procédés pour les préparer et les utiliser. Ces composés sont utiles pour traiter des affections ou des maladies dans lesquelles une modification de l'activité de l'ERK aurait un résultat thérapeutique positif, par exemple, divers cancers, le psoriasis et la kératose actinique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)