WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012094193) METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/094193    International Application No.:    PCT/US2011/067347
Publication Date: 12.07.2012 International Filing Date: 27.12.2011
IPC:
C12N 5/074 (2010.01), C12N 5/0735 (2010.01), C12N 5/10 (2006.01), C12N 15/86 (2006.01), C12N 5/02 (2006.01), A61K 48/00 (2006.01)
Applicants: BLUEBIRD BIO, INC. [US/US]; 840 Memorial Drive Cambridge, Massachusetts 02139 (US) (For All Designated States Except US).
DOWN, Julian David [GB/US]; (US) (For US Only).
LEBOULCH, Philippe Louis [FR/FR]; (FR) (For US Only)
Inventors: DOWN, Julian David; (US).
LEBOULCH, Philippe Louis; (FR)
Agent: MCDONALD, Michael J.; Cooley LLP 777 6th Street, NW Suite 1100 Washington, District of Columbia 20001 (US)
Priority Data:
61/429,401 03.01.2011 US
61/470,941 01.04.2011 US
Title (EN) METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS
(FR) PROCÉDÉS POUR AMÉLIORER L'ADMINISTRATION DE CELLULES TRANSDUITES AVEC UN GÈNE
Abstract: front page image
(EN)The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders.
(FR)Cette invention concerne de nouveaux procédés pour améliorer l'administration de cellules transduites à un sujet, qui comprennent à la fois des procédés de sélection de cellules transduites et des procédés destinés à améliorer la reconstitution par les cellules transduites chez le receveur de la greffe. Cette invention concerne, en outre, des vecteurs de transfert, comprenant des vecteurs lentiviraux, utiles pour la mise en œuvre des procédés de la présente invention. Les procédés et les vecteurs selon l'invention peuvent être utilisés en thérapie génique pour diverses maladies et affections comprenant, entre autres, les maladies et les affections hématologiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)