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1. (WO2012093411) PROCESS FOR THE PREPARATION OF R-(-)-3- (CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND THE INTERMEDIATES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/093411 International Application No.: PCT/IN2012/000024
Publication Date: 12.07.2012 International Filing Date: 09.01.2012
IPC:
C07C 227/04 (2006.01) ,C07C 231/18 (2006.01) ,C07C 231/20 (2006.01) ,C07C 233/05 (2006.01) ,C07C 229/08 (2006.01)
Applicants: Dr. Braja Sundar Pradhan[IN/IN]; IN
Inventors: Dr. Braja Sundar Pradhan; IN
Agent: FOX MANDAL & ASSOCIATES; FM House, #25, HUDA Residential Complex, Road No. 02, Banjara Hills Hyderabad- 500033 Andhra Pradesh, IN
Priority Data:
2484/CHE/201120.07.2011IN
3398/CHE/201012.01.2011IN
57/CHE/201107.01.2011IN
Title (EN) PROCESS FOR THE PREPARATION OF R-(-)-3- (CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND THE INTERMEDIATES
(FR) MÉTHODE DE PRÉPARATION D'ACIDE R-(-)-3-(CARBAMOYLMÉTHYL)-5-MÉTHYLHEXANOÏQUE ET DE SES INTERMÉDIAIRES
Abstract: front page image
(EN) The invention provides a process for resolution of R (±) - 3- (carbamoylmethyl)-5-methylhexanoic acid I to form enantiomerically pure form of compound of formula (I), the said process comprises resolution of racemic mixture of compound of formula (II) with cinchona class of alkaloids or amines. The invention also provides for a process for preparing (S)-3-(aminomethyl)-5- methylhexanoic acid from R (-)-3-(carbamoylmethyl)-5-methylhexanoic acid I.
(FR) L'invention concerne une méthode de résolution d'acide R(±)-3-(carbamoylméthyl)-5-méthylhexanoïque (I) destinée à préparer une forme énantiomériquement pure d'un composé de formule (I). Cette méthode comprend la résolution d'un mélange racémique d'un composé de formule (II) avec des alcaloïdes ou des amines de la classe du quinquina. L'invention concerne également une méthode de préparation d'acide (S)-3-(aminométhyle)-5-méthylhexanoïque à partir de l'acide R(-)-3-(carbamoylméthyl)-5-méthylhexanoïque (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)