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1. (WO2012093162) BIOSENSOR FOR DETECTING THE PRESENCE OF PROTEASES AND OPTIONALLY QUANTIFYING THE ENZYMATIC ACTIVITY THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/093162 International Application No.: PCT/EP2012/050158
Publication Date: 12.07.2012 International Filing Date: 05.01.2012
IPC:
C12Q 1/37 (2006.01) ,G01N 33/543 (2006.01) ,G01N 33/573 (2006.01) ,G01N 33/574 (2006.01) ,C07K 17/14 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
37
involving peptidase or proteinase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
573
for enzymes or isoenzymes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
14
Peptides being immobilised on, or in, an inorganic carrier
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES [FR/FR]; 25 rue Leblanc Bâtiment "Le Ponant D" F-75015 Paris, FR (AllExceptUS)
ALOUINI, Mohamed Anis [TN/TN]; TN (UsOnly)
BERTHELOT, Thomas [FR/FR]; FR (UsOnly)
MOUSTOIFA, El Farouck [FR/FR]; FR (UsOnly)
ALBENQUE-RUBIO, Sandra [FR/FR]; FR (UsOnly)
DELERIS, Gérard [FR/FR]; FR (UsOnly)
Inventors:
ALOUINI, Mohamed Anis; TN
BERTHELOT, Thomas; FR
MOUSTOIFA, El Farouck; FR
ALBENQUE-RUBIO, Sandra; FR
DELERIS, Gérard; FR
Agent:
ILGART, Jean-Christophe; BREVALEX 95 rue d'Amsterdam F-75378 Paris Cedex 8, FR
Priority Data:
11 5010006.01.2011FR
Title (EN) BIOSENSOR FOR DETECTING THE PRESENCE OF PROTEASES AND OPTIONALLY QUANTIFYING THE ENZYMATIC ACTIVITY THEREOF
(FR) BIOCAPTEUR POUR LA DETECTION DE LA PRESENCE DE PROTEASES ET EVENTUELLEMENT LA QUANTIFICATION DE L'ACTIVITE ENZYMATIQUE DE CELLES-CI
Abstract:
(EN) The present invention relates to a biosensor for detecting the presence and/or the enzymatic activity of at least one protease, which corresponds to a biosensor comprising a substrate functionalized with organic compounds comprising at least one cage-forming group, which cage-forming group is complexed with at least one group of a compound comprising a peptide sequence which is a target for the protease(s) of which it is desired to determine the presence and/or the enzymatic activity.
(FR) La présente invention a trait à un biocapteur pour la détection de la présence et/ou de l'activité enzymatique d'au moins une protéase, qui correspond à un biocapteur comprenant un support fonctionnalisé par des composés organiques comprenant au moins un groupe formant cage, lequel groupe formant cage est complexé avec au moins un groupe d'un composé comprenant une séquence peptidique cible de la ou les protéases dont on veut déterminer la présence et/ou l'activité enzymatique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP2661502