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1. (WO2012093132) PLASMINOGEN AND PLASMIN VARIANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/093132    International Application No.:    PCT/EP2012/050074
Publication Date: 12.07.2012 International Filing Date: 04.01.2012
IPC:
C12N 9/68 (2006.01), A61K 38/48 (2006.01)
Applicants: THROMBOGENICS NV [BE/BE]; Gaston Geenslaan 1 B-3001 Heverlee (BE) (For All Designated States Except US).
ZWAAL, Richard Reinier [NL/BE]; (BE) (For US Only)
Inventors: ZWAAL, Richard Reinier; (BE)
Priority Data:
11150246.4 05.01.2011 EP
61/429,868 05.01.2011 US
Title (EN) PLASMINOGEN AND PLASMIN VARIANTS
(FR) VARIANTES DE PLASMINOGÈNE ET DE PLASMINE
Abstract: front page image
(EN)The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatylic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.
(FR)L'invention concerne des variantes de plasminogène et de plasmine comprenant une ou plusieurs mutations ponctuelles dans le domaine catalytique qui réduisent ou préviennent la destruction autocatalytique de l'activité protéase de la plasmine. Des compositions, des utilisations et des procédés d'utilisation desdites variantes de plasminogène et de plasmine sont également décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)