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1. (WO2012093091) NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/093091    International Application No.:    PCT/EP2012/000040
Publication Date: 12.07.2012 International Filing Date: 05.01.2012
IPC:
C07H 15/26 (2006.01), A61K 31/7048 (2006.01), A61P 35/04 (2006.01)
Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM [DE/DE]; Im Neuenheimer Feld 280 69120 Heidelberg (DE) (For All Designated States Except US).
SCHWARTZ-ALBIEZ, Reinhard [DE/DE]; (DE) (For US Only).
MARANO, Grazia [DE/DE]; (DE) (For US Only).
FREI, Eva [DE/DE]; (DE) (For US Only).
FRANK, Martin [DE/DE]; (DE) (For US Only).
MEISTER, Betina [DE/DE]; (DE) (For US Only)
Inventors: SCHWARTZ-ALBIEZ, Reinhard; (DE).
MARANO, Grazia; (DE).
FREI, Eva; (DE).
FRANK, Martin; (DE).
MEISTER, Betina; (DE)
Agent: SCHÜSSLER, Andrea; Huber & Schüssler Truderingerstr. 246 81825 München (DE)
Priority Data:
11000103.9 07.01.2011 EP
Title (EN) NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION
(FR) NOUVEAUX ANALOGUES DE GLUCIDES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'ANGIOGENÈSE ET DE LA FORMATION DE MÉTASTASES
Abstract: front page image
(EN)The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell - surface. Exemplary compounds are: formulae (I), (II), (III), (IV).
(FR)La présente invention concerne des analogues de glucides qui, à faibles concentrations, présentent une meilleure activité biologique que des analogues de glucides déjà connus en termes d'inhibition de l'angiogenèse et de la formation de métastases, et ce en inhibant l'adhésion et/ou la migration de cellules cancéreuses humaines, en particulier à des concentrations inférieures à 5 mM. L'invention porte, en outre, sur des compositions pharmaceutiques comprenant lesdits analogues de glucides. Les composés de la présente invention peuvent être utilisés en tant qu'analogues de structures de la surface cellulaire, et c'est ainsi qu'ils peuvent avoir une influence sur les interactions cellule-cellule et cellule-matrice extracellulaire, qui sont régulées par des liaisons protéine-protéine, glucide-glucide ou glucide-lectine sur la surface cellulaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)