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1. (WO2012092645) NOVEL ANTISENSE OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/092645    International Application No.:    PCT/AU2011/001656
Publication Date: 12.07.2012 International Filing Date: 22.12.2011
IPC:
C12N 15/113 (2010.01), A61P 11/06 (2006.01), A61P 35/02 (2006.01), A61K 48/00 (2006.01), A61P 19/02 (2006.01)
Applicants: CO-OPERATIVE RESEARCH CENTRE FOR ASTHMA AND AIRWAYS [AU/AU]; Level 3 431 Glebe Point Road Glebe, New South Wales 2037 (AU) (For All Designated States Except US).
WILTON, Stephen Donald [AU/AU]; (AU) (For US Only).
THOMPSON, Philip John [AU/AU]; (AU) (For US Only).
MITRPANT, Chalermchai [TH/TH]; (TH) (For US Only).
SHELTON, Bradley [AU/AU]; (AU) (For US Only).
PRICE, Loren Louise [AU/AU]; (AU) (For US Only).
BALTIC, Svetlana [AU/AU]; (AU) (For US Only)
Inventors: WILTON, Stephen Donald; (AU).
THOMPSON, Philip John; (AU).
MITRPANT, Chalermchai; (TH).
SHELTON, Bradley; (AU).
PRICE, Loren Louise; (AU).
BALTIC, Svetlana; (AU)
Agent: WRAYS; 56 Ord Street West Perth, Western Australia 6005 (AU)
Priority Data:
2011900015 04.01.2011 AU
Title (EN) NOVEL ANTISENSE OLIGONUCLEOTIDES
(FR) NOUVEAUX OLIGONUCLÉOTIDES ANTISENS
Abstract: front page image
(EN)A purified and isolated antisense molecule capable of binding to a selected target site to induce exon skipping and/or translation blocking in the granulocyte macrophage colony-stimulating factor gene (GM-CSF) selected from the antisense molecules of SEQ ID NO: 1 to 17. Methods of treating conditions associated with abnormal levels of GM- CSF such as asthma, rheumatoid arthritis, acute myeloid leukaemia are also disclosed.
(FR)La présente invention concerne une molécule antisens purifiée et isolée capable de se lier à un site cible déterminé pour induire un saut d'exon et/ou un blocage de traduction dans le gène codant pour le facteur de croissance hématopoïétique (GM-CSF) choisie à partir des molécules antisens de SEQ ID n° 1 à 17. L'invention concerne également des procédés permettant de traiter des pathologies associées à des concentrations anormales de GM-CSF comme l'asthme, la polyarthrite rhumatoïde, la leucémie myéloïde aiguë.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)