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1. (WO2012092531) HER3 PROTEIN SRM/MRM ASSAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/092531    International Application No.:    PCT/US2011/067998
Publication Date: 05.07.2012 International Filing Date: 29.12.2011
IPC:
C07K 16/18 (2006.01)
Applicants: EXPRESSION PATHOLOGY, INC. [US/US]; 9620 Medical Center Drive, Suite 100 Rockville, MD 20850 (US) (For All Designated States Except US).
KRIZMAN, David, B. [US/US]; (US) (For US Only).
HEMBROUGH, Todd [US/US]; (US) (For US Only).
THYPARAMBIL, Sheeno [US/US]; (US) (For US Only)
Inventors: KRIZMAN, David, B.; (US).
HEMBROUGH, Todd; (US).
THYPARAMBIL, Sheeno; (US)
Agent: BOOTH, Paul, M.; Perkins Coie LLP 1201 Third Avenue Suite 4800 Seattle, WA 98101-3099 (US)
Priority Data:
61/428,147 29.12.2010 US
Title (EN) HER3 PROTEIN SRM/MRM ASSAY
(FR) ANALYSE PAR SRM/MRM DE PROTÉINES HER3
Abstract: front page image
(EN)The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the Receptor Tyrosine-Protein Kinase erbB-3, or Her3. that are particularly advantageous for quantifying the Her3 protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
(FR)La présente invention concerne des peptides spécifiques, et des caractéristiques d'ionisation dérivées des peptides, issus du récepteur à activité tyrosine kinase ernB-3 ou Her3, qui sont particulièrement avantageux pour la quantification de la protéine Her3 directement dans des échantillons biologiques fixés dans du formol par le procédé de spectrométrie de masse en mode surveillance de réaction choisie (SRM), également appelé spectrométrie de masse en mode surveillance de réactions multiples (MRM). De tels échantillons biologiques sont conservés et fixés chimiquement, ledit échantillon biologique étant choisi parmi des tissus et des cellules traités par des agents/fixateurs contenant du formaldéhyde, notamment des tissus/cellules fixés au formol, des tissus/cellules inclus dans la paraffine et fixés au formol (FFPE), des blocs de tissus FFPE et des cellules obtenues à partir de ces blocs, ainsi que des cellules de culture tissulaire qui ont été fixées dans le formol et/ou incorporées dans la paraffine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)