WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012092526) METHODS AND SYSTEMS FOR TREATMENT OF MIGRAINES AND OTHER INDICATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/092526    International Application No.:    PCT/US2011/067991
Publication Date: 05.07.2012 International Filing Date: 29.12.2011
IPC:
A61K 38/00 (2006.01)
Applicants: STRATEGIC SCIENCE & TECHNOLOGIES, LLC [US/US]; 58 Charles Street Cambridge, MA 02141 (US) (For All Designated States Except US).
FOSSEL, Eric, T. [US/US]; (US) (For US Only)
Inventors: FOSSEL, Eric, T.; (US)
Agent: WALLER, Patrick, R., H.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/428,017 29.12.2010 US
61/428,213 29.12.2010 US
Title (EN) METHODS AND SYSTEMS FOR TREATMENT OF MIGRAINES AND OTHER INDICATIONS
(FR) MÉTHODES ET SYSTÈMES DE TRAITEMENT DE MIGRAINES ET AUTRES INDICATIONS
Abstract: front page image
(EN)The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising ergopeptines, triptans, and other compounds, including salts and derivatives of these, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40°C (at least about 104°F), as compared to compositions lacking one or more of these.
(FR)L'invention concerne en général l'administration transdermique de divers composés. Selon certains aspects de l'invention, l'administration transdermique peut être facilitée par l'utilisation d'un environnement biophysique hostile. Un ensemble de modes de réalisation divulguent une composition à administration locale comprenant des ergopeptines, des triptans et d'autres composés, dont des sels et dérivés de ceux-ci, et éventuellement, un environnement biophysique hostile et/ou un donneur d'oxyde nitrique. Dans certains cas, la composition peut être stabilisée au moyen d'une combinaison d'un polymère de stabilisation (tel que la gomme de xanthane, le KELTROL® BT et/ou le KELTROL® RD), de propylène glycol, et d'un tensioactif de polysorbate tel que le Polysorbate 20, combinaison conférant, contre toute attente, une thermostabilité à la composition, par exemple à des températures élevées comme au moins 40°C (environ 104°F), par rapport aux compositions ne comprenant pas un ou plusieurs de ces éléments.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)