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Machine translation
1. (WO2012092379) CELLS HAVING DISRUPTED EXPRESSION OF PROTEINS INVOLVED IN ADME AND TOXICOLOGY PROCESSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/092379    International Application No.:    PCT/US2011/067608
Publication Date: 05.07.2012 International Filing Date: 28.12.2011
IPC:
C12N 5/071 (2010.01), C12N 15/09 (2006.01)
Applicants: SIGMA-ALDRICH CO. LLC [US/US]; 3050 Spruce Street St. Louis, Missouri 63103 (US) (For All Designated States Except US).
BOURNER, Maureen [US/US]; (US) (For US Only).
BRAYMAN, Timothy [US/US]; (US) (For US Only).
DAVIS, Gary [US/US]; (US) (For US Only).
MITCHELL, Michael D. [US/US]; (US) (For US Only).
THOMPSON, David C. [US/US]; (US) (For US Only).
XIAO, Yongling [US/US]; (US) (For US Only)
Inventors: BOURNER, Maureen; (US).
BRAYMAN, Timothy; (US).
DAVIS, Gary; (US).
MITCHELL, Michael D.; (US).
THOMPSON, David C.; (US).
XIAO, Yongling; (US)
Agent: BISSEN, Shirley T.; Polsinelli Shughart PC 100 South Fourth Street, Suite 1000 St. Louis, Missouri 63102-1825 (US)
Priority Data:
61/427,969 29.12.2010 US
61/452,842 15.03.2011 US
61/452,846 15.03.2011 US
Title (EN) CELLS HAVING DISRUPTED EXPRESSION OF PROTEINS INVOLVED IN ADME AND TOXICOLOGY PROCESSES
(FR) CELLULES DONT L'EXPRESSION DES PROTÉINES IMPLIQUÉES DANS LES PROCESSUS ADME ET TOXICOLOGIQUES EST PERTURBÉE
Abstract: front page image
(EN)The present invention provides cells comprising disrupted expression of at least one membrane transporter, drug metabolizing enzyme, xenobiotic sensor, or cellular stress response pathway protein. Also provided are methods for assessing the effect of an agent in the cells disclosed herein relative to comparable control cells.
(FR)Cette invention concerne des cellules dont l'expression d'au moins un transporteur de membrane, une enzyme de métabolisation des médicaments, un capteur xénobiotique, ou une protéine de la voie de réponse du stress cellulaire est perturbée. Des procédés pour évaluer l'effet d'un agent dans les cellules ci-décrites par rapport à des cellules témoins comparables sont également décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)