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Pub. No.:    WO/2012/092376    International Application No.:    PCT/US2011/067596
Publication Date: 05.07.2012 International Filing Date: 28.12.2011
G01N 33/53 (2006.01), C12Q 1/68 (2006.01), C07K 16/00 (2006.01), C12Q 1/02 (2006.01), C12N 5/0781 (2010.01), C12N 15/12 (2006.01)
Applicants: BIOATLA LLC [US/US]; 11011 Torreyana Road San Diego, CA 92121 (US) (For All Designated States Except US).
SHORT, Jay, M. [US/US]; (US) (For US Only)
Inventors: SHORT, Jay, M.; (US)
Agent: DUNLEAVY, Kevin, J.; Mendelsohn, Drucker, & Dunleavy, P.C. 1500 John F. Kennedy Blvd., Suite 312 Philadelphia, PA 19102 (US)
Priority Data:
61/429,004 31.12.2010 US
61/429,690 04.01.2011 US
Abstract: front page image
(EN)The present invention relates to methods for efficiently generating recombinant monoclonal antibodies derived from B cells of a non-human host which has been immunochallenged with one or more target antigens. The methods comprise the steps of identifying and isolating B cell that bind to the antigen by FACS, and recombining and enriching for thousands of cells to create a B cell library. Related products and methods, such as methods of producing expression libraries, are also disclosed.
(FR)Cette invention concerne des procédés permettant de générer efficacement des anticorps monoclonaux recombinants dérivés des cellules B d'un hôte non humain qui a été provoqué immunologiquement avec un ou plusieurs antigènes cibles. Les procédés comprennent les étapes consistant à identifier et à isoler une cellule B qui se lie à l'antigène par FACS, et à recombiner et à créer des milliers de cellules pour élaborer une banque de cellules B. Des produits et des procédés apparentés, tels que des procédés de production de banques d'expression, sont également décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)