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Machine translation
1. (WO2012092049) BROWN ADIPOCYTE MODIFICATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/092049    International Application No.:    PCT/US2011/066358
Publication Date: 05.07.2012 International Filing Date: 21.12.2011
IPC:
A61K 48/00 (2006.01), C12N 5/00 (2006.01), C12N 5/02 (2006.01), C12N 15/00 (2006.01)
Applicants: ETHICON ENDO-SURGERY, INC. [US/US]; 4545 Creek Road Cincinnati, OH 45242-2803 (US) (For All Designated States Except US).
THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL [US/US]; 55 Fruit Street Boston, MA 02114 (US) (For All Designated States Except US).
KAPLAN, Lee M. [US/US]; (US) (For US Only).
STYLOPOULOS, Nicholas [GR/US]; (US) (For US Only).
HARRIS, Jason L. [US/US]; (US) (For US Only).
HENNINGER, Dwight [US/US]; (US) (For US Only).
ARONHALT, Taylor W. [US/US]; (US) (For US Only).
VOEGELE, James W. [US/US]; (US) (For US Only)
Inventors: KAPLAN, Lee M.; (US).
STYLOPOULOS, Nicholas; (US).
HARRIS, Jason L.; (US).
HENNINGER, Dwight; (US).
ARONHALT, Taylor W.; (US).
VOEGELE, James W.; (US)
Agent: GEARY, William C. III; Nutter McClennen & Fish LLP Seaport West 155 Seaport Boulevard Boston, MA 02210-2604 (US)
Priority Data:
61/427,968 29.12.2010 US
Title (EN) BROWN ADIPOCYTE MODIFICATION
(FR) MODIFICATION DES ADIPOCYTES BRUNS
Abstract: front page image
(EN)Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.
(FR)La présente invention concerne des procédés et des produits thérapeutiques destinés à traiter des troubles métaboliques par augmentation de l'activation du tissu adipeux brun. Généralement, les procédés et les produits thérapeutiques peuvent augmenter l'activation du tissu adipeux brun pour augmenter la dépense énergétique et la perte de poids. Dans un mode de réalisation, un procédé d'augmentation de l'activation du tissu adipeux brun comprend la modification des adipocytes bruns afin qu'ils expriment un gène qui active les adipocytes bruns, comme la protéine découplante 1. Dans un autre mode de réalisation, la présente invention concerne un procédé d'augmentation de l'activation du tissu adipeux brun qui comprend l'augmentation du nombre d'adipocytes bruns. Ceci peut être réalisé par induction de la prolifération d'adipocytes in vivo ou expansion des adipocytes ex vivo, transplantation d'adipocytes dans des dépôts de tissu adipeux brun ou ailleurs et induction de la différenciation des cellules progénitrices adipocytaires, par exemple les MSC, les cellules progénitrices adipocytaires, les pré-adipocytes et les cellules précurseurs des adipocytes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)