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1. (WO2012090223) POLY(ETHER IMINE) DENDRIMERS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/090223 International Application No.: PCT/IN2011/000898
Publication Date: 05.07.2012 International Filing Date: 28.12.2011
IPC:
C08G 73/02 (2006.01) ,A61K 47/30 (2006.01) ,B82Y 5/00 (2011.01) ,A61K 9/51 (2006.01) ,A61K 48/00 (2006.01) ,C08G 83/00 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
73
Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen, with or without oxygen or carbon, not provided for in groups C08G12/-C08G71/238
02
Polyamines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
83
Macromolecular compounds not provided for in groups C08G2/-C08G81/104
Applicants: JAYARAMAN, Narayanaswamy[IN/IN]; IN (UsOnly)
THANKAPPAN, Padinjaremattathil Ullas[IN/IN]; IN (UsOnly)
MADHUSUDANA, Narayan Shampur[IN/IN]; IN (UsOnly)
DESAI, Anita[IN/IN]; IN (UsOnly)
JAYAMURUGAN, Govindasamy[IN/IN]; IN (UsOnly)
YAMAJALA BHASKARA RAMA DURGA, Rajesh[IN/IN]; IN (UsOnly)
INDIAN INSTITUTE OF SCIENCE[IN/IN]; Indian Institute of Science Bangalore 560012, IN (AllExceptUS)
NATIONAL INSTITUTE OF MENTAL HEALTH & NEUROSCIENCES[IN/IN]; National Institute Of Mental Health & Neurosciences Bangalorre 560029, IN (AllExceptUS)
Inventors: JAYARAMAN, Narayanaswamy; IN
THANKAPPAN, Padinjaremattathil Ullas; IN
MADHUSUDANA, Narayan Shampur; IN
DESAI, Anita; IN
JAYAMURUGAN, Govindasamy; IN
YAMAJALA BHASKARA RAMA DURGA, Rajesh; IN
Agent: VARADACHARI, Lakshmikumaran; Lakshmikumaran & Sridharan B-6/10, Safdarjung Enclave New Delhi 110029, IN
Priority Data:
4010/CHE/201029.12.2010IN
Title (EN) POLY(ETHER IMINE) DENDRIMERS AND USES THEREOF
(FR) DENDRIMÈRES POLY(ÉTHERIMINE) ET LEURS UTILISATIONS
Abstract:
(EN) Non-viral poly(ether imine) (PETIM) dendrimers based gene delivery systems is disclosed herein, wherein the PETIM dendrimer constituted with tertiary amine branch points, n-propyl ether linkers and primary amines, with and without further functionalizations, at their peripheries, exhibits significantly reduced toxicities, over a broad concentration range. The dendrimer complexes pDNA effectively, protects DNA from endosomal damages and delivers to cell nucleus.
(FR) L'invention concerne des systèmes d'apport de gènes à base de dendrimères poly(éhterimine) (PETIM) non viraux. Le dendrimère PETIM constitué de points de ramification d'amine tertiaire, de lieurs n-propyle éther et d'amines primaires, avec ou sans autres fonctionnalisations, au niveau e leurs périphéries, présente des toxicités considérablement réduites sur une large plage de concentration. Ledit dendrimère complexe efficacement l'ADNp, protège l'ADN d'éventuels dommages endosomaux et le véhicule jusqu'au noyau cellulaire
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)