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1. WO2012088461 - LINKER PEPTIDES AND POLYPEPTIDES COMPRISING SAME

Publication Number WO/2012/088461
Publication Date 28.06.2012
International Application No. PCT/US2011/066947
International Filing Date 22.12.2011
IPC
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
CPC
C07K 16/241
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
241Tumor Necrosis Factors
C07K 16/2875
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2875against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
C07K 16/468
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
C07K 2317/51
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
51Complete heavy chain or Fd fragment, i.e. VH + CH1
C07K 2317/622
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
60characterized by non-natural combinations of immunoglobulin fragments
62comprising only variable region components
622Single chain antibody (scFv)
Applicants
  • BIOGEN IDEC INC. [US]/[US] (AllExceptUS)
  • MILLER, Brian, Robert [US]/[US] (UsOnly)
  • GLASER, Scott [US]/[US] (UsOnly)
  • CARAVELLA, Justin [US]/[US] (UsOnly)
  • FOLEY, Susan [US]/[US] (UsOnly)
  • HRONOWSKI, Xiaoping [US]/[US] (UsOnly)
  • AIVAZIAN, Tigran, Dikran [US]/[US] (UsOnly)
Inventors
  • MILLER, Brian, Robert
  • GLASER, Scott
  • CARAVELLA, Justin
  • FOLEY, Susan
  • HRONOWSKI, Xiaoping
  • AIVAZIAN, Tigran, Dikran
Agents
  • MILASINCIC, Debra, J.
Priority Data
61/426,99323.12.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LINKER PEPTIDES AND POLYPEPTIDES COMPRISING SAME
(FR) PEPTIDES COUPLEURS ET POLYPEPTIDES LES COMPORTANT
Abstract
(EN)
The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of posttranslational modifications to the polypeptides which comprise them. More specifically, the novel linker peptides disclosed herein reduce the ability of enzymes to link carbohydrate adducts to polypeptides comprising these linker peptides, e.g., reduce the ability of xylosyltransferase to link xylose to polypeptides. These novel linker peptides, molecules comprising same, and methods of their use are described.
(FR)
L'invention concerne, au moins en partie, la découverte que des peptides coupleurs, qui sont dépourvus de la séquence d'acides aminés GSG, réduisent ou éliminent l'ajout de modifications post-traductionnelles aux polypeptides qui les comportent. Plus particulièrement, les nouveaux peptides coupleurs selon la présente invention réduisent la capacité des enzymes à lier des adduits glucidiques à des polypeptides comportant ces peptides coupleurs, par exemple réduisent la capacité de la xylosyltransférase à lier le xylose aux polypeptides. L'invention concerne ces nouveaux peptides coupleurs, des molécules les comportant et des procédés pour leur utilisation.
Also published as
Latest bibliographic data on file with the International Bureau