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1. (WO2012088425) GAP JUNCTION-ENHANCING AGENTS FOR TREATMENT OF NECROTIZING ENTEROCOLITIS AND INFLAMMATORY BOWEL DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/088425 International Application No.: PCT/US2011/066861
Publication Date: 28.06.2012 International Filing Date: 22.12.2011
IPC:
A61K 31/40 (2006.01) ,A61K 38/08 (2006.01) ,A61P 1/00 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; 200 Gardner Steel Conference Center Pittsburgh, PA 15260, US (AllExceptUS)
HACKAM, David, J. [US/US]; US (UsOnly)
Inventors:
HACKAM, David, J.; US
Agent:
KOLE, Lisa, B.; Baker Botts L.L.P. 30 Rockefeller Plaza New York, NY 10112-4498, US
Priority Data:
61/426,16222.12.2010US
Title (EN) GAP JUNCTION-ENHANCING AGENTS FOR TREATMENT OF NECROTIZING ENTEROCOLITIS AND INFLAMMATORY BOWEL DISEASE
(FR) AGENTS FAVORISANT LES JONCTIONS COMMUNICANTES UTILISABLES EN VUE DU TRAITEMENT DE L'ENTÉROCOLITE NÉCROSANTE ET DES AFFECTIONS INTESTINALES INFLAMMATOIRES NON SPÉCIFIQUES
Abstract:
(EN) The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis ("NEC") or inflammatory bowel disease ("IBD") comprising administering, to a subject in need of such treatment, an effective amount of a gap junction enhancing agent ("GJEA"), for example a peptide ("GJP") or peptide analog ("GJPA"). It is based, at least in part, on the discovery that greater functionality of gap junctions between enterocytes increases their rate of migration and reduces the severity of intestinal inflammation.
(FR) La présente invention concerne des méthodes permettant de limiter les risques de survenue de l'entérocolite nécrosante (« NEC ») ou des affections intestinales inflammatoires non spécifiques (« IBD ») et/ou de les traiter. Lesdites méthodes font appel à l'administration à un sujet ayant besoin d'un tel traitement, d'une quantité efficace d'un agent favorisant les jonctions communicantes (« GJEA »), par exemple un peptide (« GJP ») ou un analogue peptidique (« GJPA »). La présente invention se fonde, au moins pour partie, sur la découverte selon laquelle un meilleur fonctionnement des jonctions communicantes entre les entérocytes accélère leur vitesse de migration et réduit la gravité de l'inflammation intestinale.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)