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1. WO2012087135 - GENETIC MARKERS SPECIFIC FOR CLOSTRIDIUM DIFFICILE RIBOTYPES 027 (NAP01/B1; RT 027) AND 078 (NAP7/8; RT 078) AND THEIR USE

Publication Number WO/2012/087135
Publication Date 28.06.2012
International Application No. PCT/NL2011/050882
International Filing Date 21.12.2011
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
C12Q 2600/142
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
142Toxicological screening, e.g. expression profiles which identify toxicity
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
16Primer sets for multiplex assays
Applicants
  • ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC [NL]/[NL] (AllExceptUS)
  • VAN LEEUWEN, Hans Christiaan [NL]/[NL] (UsOnly)
  • CORVER, Jeroen [NL]/[NL] (UsOnly)
  • KNETSCH, Cornelis Willem [NL]/[NL] (UsOnly)
  • KUIJPER, Eduard [NL]/[NL] (UsOnly)
Inventors
  • VAN LEEUWEN, Hans Christiaan
  • CORVER, Jeroen
  • KNETSCH, Cornelis Willem
  • KUIJPER, Eduard
Agents
  • JANSEN, C.M.
Priority Data
10196587.922.12.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENETIC MARKERS SPECIFIC FOR CLOSTRIDIUM DIFFICILE RIBOTYPES 027 (NAP01/B1; RT 027) AND 078 (NAP7/8; RT 078) AND THEIR USE
(FR) MARQUEURS GÉNÉTIQUES SPÉCIFIQUES POUR CLOSTRIDIUM DIFFICILE RIBOTYPES 027 (NAP01/B1; RT 027) ET 078 (NAP7/8; RT 078) ET LEUR UTILISATION
Abstract
(EN)
The present invention relates to biomarkers unique to a Clostridium difficile hypervirulent ribotypes 027 and 078; a method for detecting, distinguishing, identifying and/or isolating and/or classifying a Clostridium difficile hypervirulent/toxigenic strain using such biomarkers in a sample or product. Primers, probes and kits for detecting Clostridium difficile (hyper) virulent strains, more in particular ribotypes 078 and 027 like (associated) strains are further provided by the invention.
(FR)
La présente invention concerne des biomarqueurs uniques pour un Clostridium difficile de ribotypes hypervirulents 027 et 078; un procédé de détection, de distinction, d'identification et/ou d'isolation et/ou de classification d'une souche de Clostridium difficile hypervirulente/toxigène en utilisant ces biomarqueurs dans un échantillon ou produit. Des amorces, des sondes et des trousses pour la détection de souches de Clostridium difficile (hyper)virulentes, plus particulièrement des souches de types de ribotypes 078 et 027 (associées) sont également décrites.
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