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1. WO2012085176 - TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS

Publication Number WO/2012/085176
Publication Date 28.06.2012
International Application No. PCT/EP2011/073734
International Filing Date 22.12.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 487/12 (2006.01)
A61K 31/4985 (2006.01)
A61P 11/00 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 487/12
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
  • HURLEY, Christopher [GB/GB]; GB (UsOnly)
  • KULAGOWSKI, Janusz [GB/GB]; GB (UsOnly)
  • MAXEY, Robert [GB/GB]; GB (UsOnly)
  • WARD, Stuart [GB/GB]; GB (UsOnly)
  • ZAK, Mark [CA/US]; US (UsOnly)
Inventors
  • HURLEY, Christopher; GB
  • KULAGOWSKI, Janusz; GB
  • MAXEY, Robert; GB
  • WARD, Stuart; GB
  • ZAK, Mark; US
Agents
  • SCHIRLIN, Julien; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data
61/427,02423.12.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS
(FR) COMPOSÉS PYRAZINONES TRICYCLIQUES, LEURS COMPOSITIONS ET LEURS PROCÉDÉS D'UTILISATION EN TANT QU'INHIBITEURS DE JANUS KINASE
Abstract
(EN)
The invention provides novel compounds of formula I having the general formula (I) wherein X, R1, R2, R3 and R5 are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
(FR)
L'invention concerne de nouveaux composés de formule I ayant la formule générale (I) où X, R1, R2, R3 et R5 sont tels que décrits présentement. Selon l'invention, les composés peuvent être apportés dans des compositions pharmaceutiquement acceptables et utilisés pour le traitement de troubles immunologiques ou hyperprolifératifs.
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