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161. (WO2012084244) A METHOD FOR THE EVALUATION OF COMPOUND-TARGET INTERACTIONS ACROSS SPECIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/084244 International Application No.: PCT/EP2011/006503
Publication Date: 28.06.2012 International Filing Date: 22.12.2011
IPC:
G01N 33/50 (2006.01) ,G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
BANTSCHEFF, Marcus [DE/DE]; DE (UsOnly)
SAVITSKI, Mikhail [SE/DE]; DE (UsOnly)
CELLZOME AG [DE/DE]; Meyerhofstr. 1 69117 Heidelberg, DE (AllExceptUS)
Inventors:
BANTSCHEFF, Marcus; DE
SAVITSKI, Mikhail; DE
Agent:
LAHRTZ, Fritz; Isenbruck Bösl Hörschler Llp Patentanwälte Eastsite one Seckenheimer Landstrasse 4 68163 Mannheim, DE
Priority Data:
10 015 931.822.12.2010EP
61/498,74420.06.2011US
Title (EN) A METHOD FOR THE EVALUATION OF COMPOUND-TARGET INTERACTIONS ACROSS SPECIES
(FR) PROCÉDÉ D'ÉVALUATION D'INTERACTIONS DE COMPOSÉ CIBLE ENTRE ESPÈCES
Abstract:
(EN) The present invention relates to a method for the determination of the species profile of a protein-interacting compound, comprising the steps of a) providing a protein preparation derived from one species (species-1) containing a species-1-variant of said protein, b) providing a protein preparation derived from another species (species-2) containing a species-2-variant of said protein, c) mixing said preparations, d) contacting said mixed protein preparations with a ligand of said protein and with a given protein-interacting compound under conditions allowing the formation of a complex between said ligand and said protein, and e) detecting the complexes formed in step d) with the help of mass spectrometry.
(FR) L'invention concerne un procédé qui vise à déterminer le profil d'espèces d'un composé interagissant avec des protéines, et qui comprend les étapes consistant à : a) réaliser une préparation de protéine dérivée d'une espèce (espèce-1) contenant une variante de l'espèce 1 de ladite protéine, b) réaliser une préparation de protéine dérivée d'une autre espèce (espèce-2) contenant une variante de l'espèce 2 de ladite protéine, c) mélanger lesdites préparations, d) mettre lesdites préparations de protéines mélangées avec un ligand de ladite protéine et avec un composé interagissant avec une protéine donnée dans des conditions permettant la formation d'un complexe entre ledit ligand et ladite protéine, et e) détecter les complexes formés à l'étape d) en utilisant la spectrométrie de masse.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)