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1. WO2012083571 - CAROTENOID OIL SUSPENSION WITH HIGH BIOAVAILABILITY AND PREPARATION METHOD THEREOF

Publication Number WO/2012/083571
Publication Date 28.06.2012
International Application No. PCT/CN2011/000156
International Filing Date 30.01.2011
IPC
A61K 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 31/01 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
A61K 31/015 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
CPC
A23D 9/007
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
9Other edible oils or fats, e.g. shortenings, cooking oils
007characterised by ingredients other than fatty acid triglycerides
A23K 20/158
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
20Accessory food factors for animal feeding-stuffs
10Organic substances
158Fatty acids; Fats; Products containing oils or fats
A23K 20/179
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
KFODDER
20Accessory food factors for animal feeding-stuffs
10Organic substances
179Colouring agents, e.g. pigmenting or dyeing agents
A61K 31/015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61K 47/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
Applicants
  • 浙江医药股份有限公司新昌制药厂 ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY [CN]/[CN] (AllExceptUS)
  • 许新德 XU, Xinde [CN]/[CN] (UsOnly)
  • 邵斌 SHAO, Bin [CN]/[CN] (UsOnly)
  • 劳学军 LAO, Xuejun [CN]/[CN] (UsOnly)
Inventors
  • 许新德 XU, Xinde
  • 邵斌 SHAO, Bin
  • 劳学军 LAO, Xuejun
Agents
  • 北京乾诚五洲知识产权代理有限责任公司 FAITHFULAW INTERNATIONAL IP LAW OFFICE
Priority Data
201010602338.623.12.2010CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CAROTENOID OIL SUSPENSION WITH HIGH BIOAVAILABILITY AND PREPARATION METHOD THEREOF
(FR) SUSPENSION D'HUILE DE CAROTÉNOÏDE PRÉSENTANT UNE BIODISPONIBILITÉ ÉLEVÉE ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种高生物利用度的类胡萝卜素油悬浮液及其制备方法
Abstract
(EN)
A carotenoid oil suspension and preparation method thereof are provided. Said method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recycling the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, said carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5μm. Said method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.
(FR)
La présente invention concerne une suspension d'huile de caroténoïde et son procédé de préparation. Ledit procédé comprend les étapes suivantes : a) mélange de caroténoïde avec un solvant organique, chauffage du mélange pour dissoudre suffisamment le caroténoïde afin d'obtenir une solution de caroténoïde ; et b) introduction de la solution de caroténoïde obtenue lors de l'étape a) dans une solution d'huile végétale remuée à grande vitesse par pulvérisation, parallèlement au recyclage du solvant organique produit durant la pulvérisation sous vide, puis simultanément achèvement du recyclage et de la pulvérisation pour obtenir la suspension d'huile de caroténoïde. Ladite suspension d'huile de caroténoïde comprend un cristal de caroténoïde possédant une taille de particule moyenne inférieure à 5 μm. Ledit procédé est applicable à l'échelle industrielle avec un fonctionnement en continu et une efficacité accrue, sans nécessiter de procédés supplémentaires de broyage de cristal de caroténoïde. Ce procédé permet de diminuer la dégradation de caroténoïde durant le processus de préparation de la suspension d'huile de caroténoïde.
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Latest bibliographic data on file with the International Bureau