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1. WO2012082974 - PH SENSOR INTEGRATION TO SINGLE USE BIOREACTOR/MIXER

Publication Number WO/2012/082974
Publication Date 21.06.2012
International Application No. PCT/US2011/065033
International Filing Date 15.12.2011
IPC
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
CPC
C12M 23/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
23Constructional details, e.g. recesses, hinges
02Form or structure of the vessel
14Bags
C12M 41/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
26of pH
C12M 41/32
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
30of concentration
32of substances in solution
C12M 41/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
30of concentration
34of gas
Applicants
  • ROSEMOUNT ANALYTICAL, INC. [US]/[US] (AllExceptUS)
  • FENG, Chang-dong [US]/[US] (UsOnly)
  • BENTON, Berry, W. [US]/[US] (UsOnly)
  • ANDERSON, Dave [US]/[US] (UsOnly)
  • YANG, Fong, S. [US]/[US] (UsOnly)
  • WOOD, Wayne, B. [US]/[US] (UsOnly)
Inventors
  • FENG, Chang-dong
  • BENTON, Berry, W.
  • ANDERSON, Dave
  • YANG, Fong, S.
  • WOOD, Wayne, B.
Agents
  • CHRISTENSON, Christopher, R.
Priority Data
61/424,24617.12.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PH SENSOR INTEGRATION TO SINGLE USE BIOREACTOR/MIXER
(FR) INTÉGRATION D'UN CAPTEUR DE PH À UN BIORÉACTEUR/MÉLANGEUR À USAGE UNIQUE
Abstract
(EN)
A pH sensing bioreaction system is provided. The system includes a bioreaction container (51) having a plastic wall (50) and a pH sensor (40, 60, 80, 100, 120) attached to the plastic wall (50). The pH sensor (40, 60, 80, 100, 120) includes a sensor body (82) having a flange (76) that is sealingly attached to the plastic wall (50). The sensor body (82) has a reference electrolyte (142) therein and a first sensing element (152) disposed in the reference electrolyte (142). The first sensing element (152) is configured to contact both the reference electrolyte (142) and a sample solution (52) inside the bioreaction container. A second sensing element (62, 92, 148) is positionable into an interior of the bioreaction container (51). The pH sensor (40, 60, 80, 100, 120) has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container (51), and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container (51).
(FR)
La présente invention concerne un système de bioréaction à détection de pH. Le système inclut un récipient de bioréaction (51) comportant une paroi en plastique (50) et un capteur de pH (40, 60, 80, 100, 120) fixé à la paroi en plastique (50). Le capteur de pH (40, 60, 80, 100, 120) inclut un corps de capteur (82) comportant une bride (76) attachée de façon étanche à la paroi en plastique (50). Le corps de capteur (82) renferme un électrolyte de référence (142) et un premier élément de détection (152) disposé dans l'électrolyte de référence (142). Le premier élément de détection (152) est configuré pour être en contact à la fois avec l'électrolyte de référence (142) et une solution d'échantillon (52) contenue dans le récipient de bioréaction. Un second élément de détection (62, 92, 148) peut être positionné à l'intérieur du récipient de bioréaction (51). Le capteur de pH (40, 60, 80, 100, 120) présente une multitude de configurations incluant une configuration gainée dans laquelle au moins un élément de détection est isolé de l'intérieur du récipient de bioréaction (51), et une configuration d'entretien dans laquelle le ou lesdits éléments de détection sont couplés de façon fluidique à l'intérieur du récipient de bioréaction (51).
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