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1. WO2012080237 - SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY

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Publication Number WO/2012/080237
Publication Date 21.06.2012
International Application No. PCT/EP2011/072593
International Filing Date 13.12.2011
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • BAYER INTELLECTUAL PROPERTY GMBH [DE]/[DE] (AllExceptUS)
  • REHWINKEL, Hartmut [DE]/[DE] (UsOnly)
  • HÄGEBARTH, Andrea [DE]/[DE] (UsOnly)
  • POLITZ, Oliver [DE]/[DE] (UsOnly)
  • NEUHAUS, Roland [DE]/[DE] (UsOnly)
  • BÖMER, Ulf [DE]/[DE] (UsOnly)
Inventors
  • REHWINKEL, Hartmut
  • HÄGEBARTH, Andrea
  • POLITZ, Oliver
  • NEUHAUS, Roland
  • BÖMER, Ulf
Common Representative
  • BAYER INTELLECTUAL PROPERTY GMBH [DE]/[DE]
Priority Data
10195397.416.12.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY
(FR) PYRIMIDO [1,2-B]INDAZOLES SUBSTITUÉS ET LEUR UTILISATION COMME MODULATEURS DE LA VOIE PI3K/AKT
front page image
Abstract
(EN)
Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
(FR)
L'invention concerne des composés de Formule (I), qui sont des inhibiteurs efficaces de la voie Pi3/Akt, leurs procédés de production et leur utilisation comme produits pharmaceutiques. Les composés de formule (I) a : sont utiles pour le traitement du cancer.
Also published as
CA2821777
EP2651949
ES2549443
JP2014501234
US20130310405
Latest bibliographic data on file with the International Bureau
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