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1. WO2012077776 - BIODEGRADABLE PARTICLES, VASCULAR OCCLUSION MATERIAL, AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES

Publication Number WO/2012/077776
Publication Date 14.06.2012
International Application No. PCT/JP2011/078510
International Filing Date 09.12.2011
IPC
A61L 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
C08G 63/12 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds
12derived from polycarboxylic acids and polyhydroxy compounds
C08G 85/00 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
85General processes for preparing compounds provided for in this subclass
CPC
A61L 2300/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
60characterised by a special physical form
A61L 24/0031
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
001Use of materials characterised by their function or physical properties
0031Hydrogels or hydrocolloids
A61L 24/0042
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
001Use of materials characterised by their function or physical properties
0042Materials resorbable by the body
A61L 24/046
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
046obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 2430/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
36for embolization or occlusion, e.g. vaso-occlusive compositions or devices
A61L 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
Applicants
  • 東レ株式会社 TORAY INDUSTRIES, INC. [JP]/[JP] (AllExceptUS)
  • 棚橋 一裕 TANAHASHI, Kazuhiro (UsOnly)
  • 中西 恵 NAKANISHI, Megumi (UsOnly)
  • 山村 泰史 YAMAMURA, Yasufumi (UsOnly)
  • 藤田 雅規 FUJITA, Masaki (UsOnly)
Inventors
  • 棚橋 一裕 TANAHASHI, Kazuhiro
  • 中西 恵 NAKANISHI, Megumi
  • 山村 泰史 YAMAMURA, Yasufumi
  • 藤田 雅規 FUJITA, Masaki
Priority Data
2010-27431209.12.2010JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) BIODEGRADABLE PARTICLES, VASCULAR OCCLUSION MATERIAL, AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES
(FR) PARTICULES BIODÉGRADABLES, MATIÈRE D'OCCLUSION VASCULAIRE ET PROCÉDÉ DE PRODUCTION DE PARTICULES BIODÉGRADABLES
(JA) 生分解性粒子、血管塞栓材料及び生分解性粒子の製造方法
Abstract
(EN)
The objective of the present invention is to provide: spherical biodegradable particles having an ameliorated insufficiency in flexibility, having resistance to the occurrence of particle agglomeration, and having an increased particle shape restoring force after passing through a catheter or the like; and a method for producing the biodegradable particles. The present invention provides biodegradable particles formed from the chemical crosslinking of a synthetic polymer and a polyvalent carboxylic acid, and having a moisture content in a water saturated state of 20-90%.
(FR)
Le but de cette invention est de produire des particules biodégradables sphériques dont le manque de flexibilité est amélioré, et qui présentent une résistance à l'agglomération, ainsi qu'une force accrue de rétablissement de leur forme après leur passage dans un cathéter ou analogue. L'invention concerne également un procédé de production de ces particules biodégradables. Les particules biodégradables de la présente invention sont formées à partir de la réticulation chimique d'un polymère synthétique et d'un acide carboxylique polyvalent et ont une teneur en humidité, à l'état saturé d'eau, de 20 à 90 %.
(JA)
本発明は、柔軟性不足が改善され、粒子同士の凝集が起こりにくく、かつ、カテーテル等を通過した後における粒子形状の復元力が向上した球状の生分解性粒子及びその製造方法を提供することを目的としている。本発明は、合成ポリマーと、多価カルボン酸とが化学架橋されてなり、飽和含水状態での含水率が20~90%である、生分解性粒子を提供する。
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