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1. WO2012076694 - CANCER GENE THERAPY USING NUCLEIC ACIDS ENCODING US28 AND G-PROTEIN

Publication Number WO/2012/076694
Publication Date 14.06.2012
International Application No. PCT/EP2011/072338
International Filing Date 09.12.2011
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A61K 48/00 (2006.01)
A61K 38/16 (2006.01)
A61P 35/00 (2006.01)
CPC
A61K 31/711
A61K 38/177
A61K 45/06
A61K 48/00
A61K 48/005
C07K 14/005
Applicants
  • MEDIZINISCHE UNIVERSITÄT GRAZ; Auenbruggerplatz 2 A-8036 Graz, AT (AllExceptUS)
  • SCHAIDER, Helmut [AT/AT]; AT (UsOnly)
  • JOSHI, Shripad [IN/AT]; AT (UsOnly)
Inventors
  • SCHAIDER, Helmut; AT
  • JOSHI, Shripad; AT
Agents
  • BEHRENS, Lueder; Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München, DE
Priority Data
10194621.810.12.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CANCER GENE THERAPY USING NUCLEIC ACIDS ENCODING US28 AND G-PROTEIN
(FR) THÉRAPIE GÉNIQUE DU CANCER UTILISANT DES ACIDES NUCLÉIQUES CODANT US28 ET UNE PROTÉINE G
Abstract
(EN)
The invention relates to the gene therapeutic treatment of cancer using co-expressed nucleic acids encoding US28 and a G-protein. e.g. GNA-13, or functional fragments thereof, or using nucleic acids encoding fusion polypeptides of US28 and a G-protein or functional fragments thereof. The pharmaceutical compositions according to the invention are used in the treatment of cancer patients to induce apoptosis in tumor cells.
(FR)
L'invention concerne un traitement thérapeutique génique du cancer utilisant des acides nucléiques co-exprimés codant US28 et une protéine G, par exemple GNA-13, ou des fragments fonctionnels associés, ou par le biais de l'utilisation d'acides nucléiques codant des polypeptides de fusion de US28 et une protéine G ou des fragments fonctionnels de celle-ci. Les compositions pharmaceutiques selon l'invention sont utilisées dans le traitement de patients souffrant du cancer pour induire l'apoptose dans des cellules tumorales.
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Latest bibliographic data on file with the International Bureau