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1. (WO2012075451) CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/075451 International Application No.: PCT/US2011/063164
Publication Date: 07.06.2012 International Filing Date: 02.12.2011
IPC:
A61K 9/22 (2006.01) ,A61K 31/415 (2006.01) ,A61K 31/41 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
Applicants:
WARSAW ORTHOPEDIC, INC. [US/US]; 2500 Silveus Crossing Warsaw, Indiana 46581, US (AllExceptUS)
WILSEY, Jared T. [US/US]; US (UsOnly)
BIGGS, Danielle L. [US/US]; US (UsOnly)
MARX, Jeffrey C. [US/US]; US (UsOnly)
MCKAY, William [US/US]; US (UsOnly)
ROY, Josee [CA/US]; US (UsOnly)
ZANELLA, John Meyers [US/US]; US (UsOnly)
Inventors:
WILSEY, Jared T.; US
BIGGS, Danielle L.; US
MARX, Jeffrey C.; US
MCKAY, William; US
ROY, Josee; US
ZANELLA, John Meyers; US
Agent:
PATEL, Samir R.; Medtronic, Inc. MS LC340 710 Medtronic Parkway Minneapolis, Minnesota 55432, US
Priority Data:
13/309,76602.12.2011US
61/419,47103.12.2010US
Title (EN) CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER
(FR) COMPOSÉS DE CLONIDINE ET GABA DANS UN VÉHICULE DE TYPE POLYMÈRE BIODÉGRADABLE
Abstract:
(EN) Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
(FR) Cette invention concerne des traitements efficaces contre la douleur pendant des périodes de temps prolongées. Grâce à l'administration d'une quantité efficace de clonidine et d'un composé d'acide gamma-aminobutyrique au, ou à proximité du, site cible, on peut soulager la douleur provoquée par diverses sources, dont entre autres, l'hernie discale (à savoir, la sciatique), le spondylolisthésis, la sténose, la douleur dorsale discogène et la douleur articulaire, ainsi que la douleur afférente à une opération chirurgicale. Quand des formulations appropriées sont administrées dans des polymères biodégradables, ce soulagement peut perdurer pendant au moins trois jours. Dans certains modes de réalisation, ce soulagement peut être porté à au moins vingt-cinq jours, au moins cinquante jours, au moins cent jours, au moins cent trente-cinq jours ou au moins cent quatre-vingts jours.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)