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1. (WO2012075440) COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE TO A TARGET TISSUE SITE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/075440 International Application No.: PCT/US2011/063147
Publication Date: 07.06.2012 International Filing Date: 02.12.2011
IPC:
A61K 9/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
Applicants:
WARSAW ORTHOPEDIC, INC. [US/US]; 2500 Silveus Crossing Warsaw, Indiana 46581, US (AllExceptUS)
WILSEY, Jared T. [US/US]; US (UsOnly)
BIGGS, Danielle L. [US/US]; US (UsOnly)
GRAY, Jonathan K. [US/US]; US (UsOnly)
MARX, Jeffrey C. [US/US]; US (UsOnly)
MCKAY, William [US/US]; US (UsOnly)
ROY, Josee [CA/US]; US (UsOnly)
ZANELLA, John Meyers [US/US]; US (UsOnly)
Inventors:
WILSEY, Jared T.; US
BIGGS, Danielle L.; US
GRAY, Jonathan K.; US
MARX, Jeffrey C.; US
MCKAY, William; US
ROY, Josee; US
ZANELLA, John Meyers; US
Agent:
PATEL, Samir R.; Medtronic, Inc. MS LC340 710 Medtronic Parkway Minneapolis, Minnesota 55432, US
Priority Data:
13/309,75902.12.2011US
61/419,45503.12.2010US
Title (EN) COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE TO A TARGET TISSUE SITE
(FR) COMPOSITIONS ET MÉTHODES D'ADMINISTRATION DE CLONIDINE EN DIRECTION D'UN TISSU CIBLE
Abstract:
(EN) Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
(FR) Cette invention concerne des traitements de la douleur se révélant efficaces sur de longues durées. L'administration d'une quantité efficace de clonidine à libération immédiate et de clonidine à libération prolongée au niveau d'un site cible ou à proximité de celui-ci, permet d'atténuer des douleurs d'origines diverses, notamment les douleurs associées à la hernie discale (sciatique), au spondylolisthésis, à la sténose, les douleurs dorsales d'origine discale et les douleurs articulaires. Lorsque les préparations appropriées intégrées dans des polymères biodégradables sont administrées, le soulagement de la douleur peut se prolonger pendant au moins trois jours. Dans certains modes de réalisation, le soulagement peut être observé sur au moins vingt-cinq jours, au moins cinquante jours, au moins cent jours, au moins cent trente-cinq jours ou au moins cent quatre-vingts jours, voire pendant encore plus longtemps.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)